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Title: Chronic inflammation and cytokines in the tumor microenvironment
Authors: Glauben Landskron
Marjorie De La Fuente
Peti Thuwajit
Chanitra Thuwajit
Marcela A. Hermoso
Universidad de Chile
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2014
Citation: Journal of Immunology Research. Vol.2014, (2014)
Abstract: Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma. © 2014 Glauben Landskron et al.
ISSN: 23147156
Appears in Collections:Scopus 2011-2015

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