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Title: Short report: Pre-existing cross-reactive antibodies to avian influenza H5N1 and 2009 pandemic H1N1 in US military personnel
Authors: Sathit Pichyangkul
Somporn Krasaesub
Anan Jongkaewwattana
Arunee Thitithanyanont
Suwimon Wiboon-ut
Kosol Yongvanitchit
Amporn Limsalakpetch
Utaiwan Kum-Arb
Duangrat Mongkolsirichaikul
Nuanpan Khemnu
Rangsini Mahanonda
Jean Michel Garcia
Carl J. Mason
Douglas S. Walsh
David L. Saunders
Armed Forces Research Institute of Medical Sciences, Thailand
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
Chulalongkorn University
HKU-Pasteur Research Centre
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2014
Citation: American Journal of Tropical Medicine and Hygiene. Vol.90, No.1 (2014), 149-152
Abstract: We studied cross-reactive antibodies against avian influenza H5N1 and 2009 pandemic (p) H1N1 in 200 serum samples from US military personnel collected before the H1N1 pandemic. Assays used to measure antibodies against viral proteins involved in protection included a hemagglutination inhibition (HI) assay and a neuraminidase inhibition (NI) assay. Viral neutralization by antibodies against avian influenza H5N1 and 2009 pH1N1 was assessed by influenza (H5) pseudotyped lentiviral particle-based and H1N1 microneutralization assays. Some US military personnel had cross-neutralizing antibodies against H5N1 (14%) and 2009 pH1N1 (16.5%). The odds of having cross-neutralizing antibodies against 2009 pH1N1 were 4.4 times higher in subjects receiving more than five inactivated whole influenza virus vaccinations than those subjects with no record of vaccination. Although unclear if the result of prior vaccination or disease exposure, these pre-existing antibodies may prevent or reduce disease severity. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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