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Title: A highly conserved region between amino acids 221 and 266 of dengue virus non-structural protein 1 Is a major epitope region in infected patients
Authors: Magot Diata Omokoko
Sabar Pambudi
Supranee Phanthanawiboon
Promsin Masrinoul
Chayanee Setthapramote
Tadahiro Sasaki
Motoki Kuhara
Pongrama Ramasoota
Akifumi Yamashita
Itaru Hirai
Kazuyoshi Ikuta
Takeshi Kurosu
Osaka University
Mahidol University
Medical & Biological Laboratories Co, Ltd
National Institute of Infectious Diseases
University of the Ryukyus
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2014
Citation: American Journal of Tropical Medicine and Hygiene. Vol.91, No.1 (2014), 146-155
Abstract: The immune response to dengue virus (DENV) infection generates high levels of antibodies (Abs) against the DENV non-structural protein 1 (NS1), particularly in cases of secondary infection. Therefore, anti-NS1 Abs may play a role in severe dengue infections, possibly by interacting (directly or indirectly) with host factors or regulating virus production. If it does play a role, NS1 may contain epitopes that mimic those epitopes of host molecules. Previous attempts to map immunogenic regions within DENV-NS1 were undertaken using mouse monoclonal Abs (MAbs). The aim of this study was to characterize the epitope regions of nine anti-NS1 human monoclonal Abs (HuMAbs) derived from six patients secondarily infected with DENV-2. These anti-NS1 HuMAbs were cross-reactive with DENV-1, -2, and -3 but not DENV-4. All HuMAbs bound a common epitope region located between amino acids 221 and 266 of NS1. This study is the first report to map a DENV-NS1 epitope region using anti-DENV MAbs derived from patients. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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