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|Title:||Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine|
William A. Denny
Thailand National Science and Technology Development Agency
Auckland Cancer Society Research Centre
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||Acta Tropica. Vol.140, No.1 (2014), 181-183|
|Abstract:||© 2014 Elsevier B.V. The hematin-targeting properties of pynacrine, an acridine analog of the schizontocidal antimalarial drug, pyronaridine, were evaluated to probe the role of the latter's benzonaphthyridine moiety. Pynacrine was as active as pyronaridine in inhibiting glutathione-induced hematin degradation and in enhancing hematin-mediated membrane lysis. It formed a 1:2 complex with hematin but was 50-fold less effective in inhibiting β-hematin formation. However, pynacrine was as potent as pyronaridine in inhibiting intraerythrocytic Plasmodium falciparum growth in culture, suggesting that it has other off-target(s) effects.|
|Appears in Collections:||Scopus 2011-2015|
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