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Title: Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine
Authors: Narumon Sereekhajornjaru
Chanat Somboon
Roonglawan Rattanajak
William A. Denny
Prapin Wilairat
Saranya Auparakkitanon
Mahidol University
Thailand National Science and Technology Development Agency
Auckland Cancer Society Research Centre
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2014
Citation: Acta Tropica. Vol.140, No.1 (2014), 181-183
Abstract: © 2014 Elsevier B.V. The hematin-targeting properties of pynacrine, an acridine analog of the schizontocidal antimalarial drug, pyronaridine, were evaluated to probe the role of the latter's benzonaphthyridine moiety. Pynacrine was as active as pyronaridine in inhibiting glutathione-induced hematin degradation and in enhancing hematin-mediated membrane lysis. It formed a 1:2 complex with hematin but was 50-fold less effective in inhibiting β-hematin formation. However, pynacrine was as potent as pyronaridine in inhibiting intraerythrocytic Plasmodium falciparum growth in culture, suggesting that it has other off-target(s) effects.
ISSN: 18736254
Appears in Collections:Scopus 2011-2015

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