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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/34099
Title: Evaluation of the diagnostic accuracy of a typhoid IgM flow assay for the diagnosis of typhoid fever in Cambodian children using a Bayesian latent class model assuming an imperfect gold standard
Authors: Catrin E. Moore
Wirichada Pan-Ngum
Lalith P.M. Wijedoru
Soeng Sona
Tran Vu Thieu Nga
Pham Thanh Duy
Phat Voong Vinh
Kheng Chheng
Varun Kumar
Kate Emary
Michael Carter
Lisa White
Stephen Baker
Nicholas P.J. Day
Christopher M. Parry
Angkor Hospital for Children
Mahidol University
Churchill Hospital
UCL
UCL Institute of Child Health
Liverpool School of Tropical Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2014
Citation: American Journal of Tropical Medicine and Hygiene. Vol.90, No.1 (2014), 114-120
Abstract: Rapid diagnostic tests are needed for typhoid fever (TF) diagnosis in febrile children in endemic areas. Five hundred children admitted to the hospital in Cambodia between 2009 and 2010 with documented fever (≥38 ° C) were investigated using blood cultures (BCs), Salmonella Typhi/Paratyphi A real-time polymerase chain reactions (PCRs), and a Typhoid immunoglobulin M flow assay (IgMFA). Test performance was determined by conventional methods and Bayesian latent class modeling. There were 32 cases of TF (10 BC- and PCR-positive cases, 14 BC-positive and PCR-negative cases, and 8 BC-negative and PCR-positive cases). IgMFA sensitivity was 59.4% (95% confidence interval = 41-76), and specificity was 97.8% (95% confidence interval = 96-99). The model estimate sensitivity for BC was 81.0% (95% credible interval = 54-99). The model estimate sensitivity for PCR was 37.8% (95% credible interval = 26-55), with a specificity of 98.2% (95% credible interval = 97-99). The model estimate sensitivity for IgMFA (≥2+) was 77.9% (95% credible interval = 58-90), with a specificity of 97.5% (95% credible interval = 95-100). The model estimates of IgMFA sensitivity and specificity were comparable with BCs and better than estimates using conventional analysis. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84892681513&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/34099
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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