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dc.contributor.authorPrasad Dasarien_US
dc.contributor.authorAnja Friesen_US
dc.contributor.authorSophia D. Heberen_US
dc.contributor.authorAbdulgabar Salamaen_US
dc.contributor.authorIgor Wolfgang Blauen_US
dc.contributor.authorKlaus Lingelbachen_US
dc.contributor.authorSebastian Chakrit Bhakdien_US
dc.contributor.authorRachanee Udomsangpetchen_US
dc.contributor.authorMichael Torzewskien_US
dc.contributor.authorKarina Reissen_US
dc.contributor.authorSucharit Bhakdien_US
dc.contributor.otherKlinikum der Johannes-Gutenberg-Universitat und Fachbereich Medizinen_US
dc.contributor.otherCharité – Universitätsmedizin Berlinen_US
dc.contributor.otherPhilipps-Universität Marburgen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherRobert Bosch Krankenhaus Stuttgarten_US
dc.contributor.otherChristian-Albrechts-Universitat zu Kielen_US
dc.identifier.citationMedical Microbiology and Immunology. Vol.203, No.6 (2014), 383-393en_US
dc.description.abstract© 2014, Springer-Verlag Berlin Heidelberg. The digestive vacuole (DV) of Plasmodium falciparum, which is released into the bloodstream upon rupture of each parasitized red blood cell (RBC), was recently discovered to activate the alternative complement pathway. In the present work, we show that C3- and C5-convertases assembling on the parasitic organelle are able to provoke deposition of activated C3 and C5b-9 on non-infected bystander erythrocytes. Direct contact of DVs with cells is mandatory for the effect, and bystander complement deposition occurs focally, possibly at the sites of contact. Complement opsonization promotes protracted erythrophagocytosis by human macrophages, an effect that is magnified when ring-stage infected RBCs with reduced CD55 and CD59, or paroxysmal nocturnal hemoglobinuria (PNH)-RBCs lacking these complement inhibitors are employed as targets. Bystander attack can also directly induce lysis of PNH-RBCs. Direct evidence for complement activation and bystander attack mediated by DVs was obtained through immunohistochemical analyses of brain paraffin sections from autopsies of patients who had died of cerebral malaria. C3d and the assembled C5b-9 complex could be detected in all sections, colocalizing with and often extending locally beyond massive accumulations of DVs that were identified under polarized light. This is the first demonstration that a complement-activating particle can mediate opsonization of bystander cells to promote their antibody-independent phagocytosis. The phenomenon may act in concert with other pathomechanisms to promote the development of anemia in patients with severe malaria.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleMalarial anemia: digestive vacuole of Plasmodium falciparum mediates complement deposition on bystander cells to provoke hemophagocytosisen_US
Appears in Collections:Scopus 2011-2015

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