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Title: Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria
Authors: Jiraporn Laothamatas
Christina L. Sammet
Xavier Golay
Marc Van Cauteren
Varinee Lekprasert
Noppadon Tangpukdee
Srivicha Krudsood
Wattana Leowattana
Polrat Wilairatana
Srirama V. Swaminathan
Robert L. DeLaPaz
Truman R. Brown
Sornchai Looareesuwan
Gary M. Brittenham
Mahidol University
Ann & Robert H. Lurie Children's Hospital of Chicago
UCL Institute of Neurology
Philips Healthcare Nederland
Columbia University in the City of New York
Medical University of South Carolina
Columbia University, College of Physicians and Surgeons
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2014
Citation: American Journal of Tropical Medicine and Hygiene. Vol.90, No.6 (2014), 1117-1123
Abstract: Patients with acute uncomplicated Plasmodium falciparum malaria have no evident neurologic disorder, vital organ dysfunction, or other severe manifestations of infection. Nonetheless, parasitized erythrocytes cytoadhere to the endothelium throughout their microvasculature, especially within the brain. We aimed to determine if 3 Tesla magnetic resonance imaging studies could detect evidence of cerebral abnormalities in these patients. Within 24 hours of admission, initial magnetic resonance imaging examinations found a lesion with restricted water diffusion in the mid-portion of the splenium of the corpus callosum of 4 (40%) of 10 male patients. The four patients who had a splenial lesion initially had evidence of more severe hemolysis and thrombocytopenia than the six patients who had no apparent abnormality. Repeat studies four weeks later found no residua of the lesions and resolution of the hematologic differences. These observations provide evidence for acute cerebral injury in the absence of severe or cerebral malaria. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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