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dc.contributor.authorJiraporn Laothamatasen_US
dc.contributor.authorChristina L. Sammeten_US
dc.contributor.authorXavier Golayen_US
dc.contributor.authorMarc Van Cauterenen_US
dc.contributor.authorVarinee Lekpraserten_US
dc.contributor.authorNoppadon Tangpukdeeen_US
dc.contributor.authorSrivicha Krudsooden_US
dc.contributor.authorWattana Leowattanaen_US
dc.contributor.authorPolrat Wilairatanaen_US
dc.contributor.authorSrirama V. Swaminathanen_US
dc.contributor.authorRobert L. DeLaPazen_US
dc.contributor.authorTruman R. Brownen_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.authorGary M. Brittenhamen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherAnn & Robert H. Lurie Children's Hospital of Chicagoen_US
dc.contributor.otherUCL Institute of Neurologyen_US
dc.contributor.otherPhilips Healthcare Nederlanden_US
dc.contributor.otherColumbia University in the City of New Yorken_US
dc.contributor.otherMedical University of South Carolinaen_US
dc.contributor.otherColumbia University, College of Physicians and Surgeonsen_US
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene. Vol.90, No.6 (2014), 1117-1123en_US
dc.description.abstractPatients with acute uncomplicated Plasmodium falciparum malaria have no evident neurologic disorder, vital organ dysfunction, or other severe manifestations of infection. Nonetheless, parasitized erythrocytes cytoadhere to the endothelium throughout their microvasculature, especially within the brain. We aimed to determine if 3 Tesla magnetic resonance imaging studies could detect evidence of cerebral abnormalities in these patients. Within 24 hours of admission, initial magnetic resonance imaging examinations found a lesion with restricted water diffusion in the mid-portion of the splenium of the corpus callosum of 4 (40%) of 10 male patients. The four patients who had a splenial lesion initially had evidence of more severe hemolysis and thrombocytopenia than the six patients who had no apparent abnormality. Repeat studies four weeks later found no residua of the lesions and resolution of the hematologic differences. These observations provide evidence for acute cerebral injury in the absence of severe or cerebral malaria. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleTransient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malariaen_US
Appears in Collections:Scopus 2011-2015

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