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Title: ICON: Chronic rhinosinusitis
Authors: Claus Bachert
Ruby Pawankar
Luo Zhang
Chaweewan Bunnag
Wytske J. Fokkens
Daniel L. Hamilos
Orathai Jirapongsananuruk
Robert Kern
Eli O. Meltzer
Joaquim Mullol
Robert Naclerio
Renata Pilan
Chae Seo Rhee
Harumi Suzaki
Richard Voegels
Michael Blaiss
University Hospital of Ghent
Nippon Medical School
Beijing Institute of Otorhinolaryngology
Mahidol University
Academic Medical Centre, University of Amsterdam
Massachusetts General Hospital
Northwestern University Feinberg School of Medicine
Allergy and Asthma Medical Group and Research Center
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS
University of Chicago
Universidade de Sao Paulo - USP
Seoul National University Bundang Hospital
Showa University
University of Tennessee Health Science Center
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2014
Citation: World Allergy Organization Journal. Vol.7, No.1 (2014)
Abstract: © 2014 Bachert et al. Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-economic impact. Moreover, the complexity of this disease due to its heterogeneous nature based on the underlying pathophysiology - leading to different disease variants - further complicates our understanding and directions for the most appropriate targeted treatment strategies. Several International/national guidelines/position papers and/or consensus documents are available that present the current knowledge and treatment strategies for CRS. Yet there are many challenges to the management of CRS especially in the case of the more severe and refractory forms of disease. Therefore, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), a collaboration between EAACI, AAAAI, ACAAI, and WAO, has decided to propose an International Consensus (ICON) on Chronic Rhinosinusitis. The purpose of this ICON on CRS is to highlight the key common messages from the existing guidelines, the differences in recommendations as well as the gaps in our current knowledge of CRS, thus providing a concise reference. In this document we discuss the definition of the disease, its relevance, pharmacoeconomics, pathophysiology, phenotypes and endotypes, genetics and risk factors, natural history and co-morbidities as well as clinical manifestations and treatment options in both adults and children comprising pharmacotherapy, surgical interventions and more recent biological approaches. Finally, we have also highlighted the unmet needs that wait to be addressed through future research.
ISSN: 19394551
Appears in Collections:Scopus 2011-2015

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