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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/34112
Title: Association between antibiotic exposure, bronchiolitis, and TLR4 (rs1927911) polymorphisms in childhood asthma
Authors: Eun Lee
Ji Won Kwon
Hyo Bin Kim
Ho Sung Yu
Mi Jin Kang
Kyungmo Hong
Song I. Yang
Young Ho Jung
Seung Hwa Lee
Kil Young Choi
Hye Lim Shin
Seo Ah Hong
Hyung Young Kim
Ju Hee Seo
Byoung Ju Kim
So Yeon Lee
Dae Jin Song
Woo Kyung Kim
Gwang Cheon Jang
Jung Yeon Shim
Soo Jong Hong
University of Ulsan, College of Medicine
Seoul National University Bundang Hospital
Inje University Paik Hospital
Goucher College
Mahidol University
Kosin University, College of Medicine
Korea Cancer Center Hospital
Hallym University
Korea University Medical Center
National Health Insurance Cooperation Ilsan Hospital
SungKyunKwan University, School of Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2014
Citation: Allergy, Asthma and Immunology Research. Vol.7, No.2 (2014), 167-174
Abstract: © Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology. The complex interplay between environmental and genetic factors plays an important role in the development of asthma. Several studies have yielded conflicting results regarding the 2 asthma-related risk factors: antibiotic usage during infancy and/or a history of bronchiolitis during early life and the development of asthma. In addition to these risk factors, we also explored the effects of Toll-like receptor 4 (TLR4) polymorphism on the development of childhood asthma. Methods: This cross-sectional study involved 7,389 middle school students who were from 8 areas of Seoul, Korea, and completed the International Study of Asthma and Allergies in Childhood questionnaire. The TLR4 polymorphism rs1927911 was genotyped in 1,395 middle school students from two areas using the TaqMan assay. Results: Bronchiolitis in the first 2 years of life, antibiotic exposure during the first year of life, and parental history of asthma were independent risk factors for the development of asthma. When combined, antibiotic use and a history of bronchiolitis increased the risk of asthma (adjusted odds ratio [aOR]: 4.64, 95% confidence interval [CI]: 3.09-6.97, P value for interaction=0.02). In subjects with CC genotype of TLR4, antibiotic exposure and a history of bronchiolitis during infancy, the risk of asthma was increased, compared to subjects without these risk factors (aOR: 5.72, 95% CI: 1.74-18.87). Conclusions: Early-life antibiotic exposures and a history of bronchiolitis are risk factors for asthma in young adolescents. Polymorphisms of TLR4 modified the influence of these environmental factors. Reducing antibiotic exposure and preventing bronchiolitis during infancy may prevent the development of asthma, especially in genetically susceptible subjects.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937834967&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/34112
ISSN: 20927363
20927355
Appears in Collections:Scopus 2011-2015

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