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Title: Retinal changes in visceral leishmaniasis by retinal photography
Authors: Richard J. Maude
BUM U.M.W. Ahmed
Abu Hayat Md Waliur Rahman
Ridwanur Rahman
Mohammed I. Majumder
Darryl B. Menezes
Abdullah Abu Sayeed
Laura Hughes
Thomas J. MacGillivray
Shyamanga Borooah
Baljean Dhillon
Arjen M. Dondorp
Mohammad A. Faiz
Mahidol University
Nuffield Department of Clinical Medicine
University of Edinburgh, College of Medicine and Veterinary Medicine
Sir Salimullah Medical College
Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust
Chittagong Medical College Hospital
University of Edinburgh
Keywords: Medicine
Issue Date: 30-Sep-2014
Citation: BMC Infectious Diseases. Vol.14, No.1 (2014)
Abstract: © 2014 Maude et al.; licensee BioMed Central Ltd. Background: In visceral leishmaniasis (VL), retinal changes have previously been noted but not described in detail and their clinical and pathological significance are unknown. A prospective observational study was undertaken in Mymensingh, Bangladesh aiming to describe in detail visible changes in the retina in unselected patients with VL.Methods: Patients underwent assessment of visual function, indirect and direct ophthalmoscopy and portable retinal photography. The photographs were assessed by masked observers including assessment for vessel tortuosity using a semi-automated system.Results: 30 patients with VL were enrolled, of whom 6 (20%) had abnormalities. These included 5 with focal retinal whitening, 2 with cotton wool spots, 2 with haemorrhages, as well as increased vessel tortuosity. Visual function was preserved.Conclusions: These changes suggest a previously unrecognized retinal vasculopathy. An inflammatory aetiology is plausible such as a subclinical retinal vasculitis, possibly with altered local microvascular autoregulation, and warrants further investigation.
ISSN: 14712334
Appears in Collections:Scopus 2011-2015

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