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Title: Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database
Authors: Azar Kariminia
Nicolas Durier
Gonzague Jourdain
Suneeta Saghayam
Chau V. Do
Lam Van Nguyen
Rawiwan Hansudewechakul
Pagakrong Lumbiganon
Kulkanya Chokephaibulkit
Khanh Huu Truong
Virat Sirisanthana
Vibol Ung
Saphonn Vonthanak
Jintanat Ananworanich
Nik Khairulddin Nik Yusoff
Nia Kurniati
Kamarul Azahar Razali
Moy Siew Fong
Revathy Nallusamy
Dewi Kumara Wati
University of New South Wales (UNSW) Australia
TREAT Asia/amfAR-The Foundation for AIDS Research
IRD Institut de Recherche pour le Developpement
Chiang Mai University
YR Gaitonde Centre for AIDS Research and Education
Children's Hospital 2
National Hospital of Pediatrics Hanoi
Chiangrai Prachanukroh Hospital
Khon Kaen University
Mahidol University
Children's Hospital 1
National Pediatric Hospital
National Center for HIV/AIDS
The HIV Netherlands Australia Thailand Research Collaboration
Hospital Raja Perempuan Zainab II
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Kuala Lumpur Hospital
Hospital Likas
Penang Hospital
Universitas Udayana
Keywords: Medicine
Issue Date: 1-Sep-2014
Citation: Journal of Acquired Immune Deficiency Syndromes. Vol.67, No.1 (2014), 71-76
Abstract: Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings. © 2014 by Lippincott Williams & Wilkins.
ISSN: 10779450
Appears in Collections:Scopus 2011-2015

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