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Title: Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia
Authors: Praphan Phanuphak
Sunee Sirivichayakul
Awachana Jiamsakul
Somnuek Sungkanuparph
Nagalingeswaran Kumarasamy
Man Po Lee
Thira Sirisanthana
Pacharee Kantipong
Christopher Lee
Adeeba Kamarulzaman
Mahiran Mustafa
Rossana Ditangco
Tuti Merati
Winai Ratanasuwan
Thida Singtoroj
Rami Kantor
The HIV Netherlands Australia Thailand Research Collaboration
Chulalongkorn University
University of New South Wales (UNSW) Australia
Mahidol University
YR Gaitonde Centre for AIDS Research and Education
Queen Elizabeth Hospital Hong Kong
Chiang Mai University
Chiangrai Prachanukroh Hospital
Hospital Sungai Buloh
University of Malaya
Hospital Raja Perempuan Zainab II
Universitas Udayana
amfAR - The Foundation for AIDS Research
Brown University
Keywords: Medicine
Issue Date: 1-May-2014
Citation: Journal of Acquired Immune Deficiency Syndromes. Vol.66, No.1 (2014), 74-79
Abstract: BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens. METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models. RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR. CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs. © 2013 by Lippincott Williams and Wilkins.
ISSN: 10779450
Appears in Collections:Scopus 2011-2015

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