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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/34267
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dc.contributor.authorPaul Gillarden_US
dc.contributor.authorDaniel Wai Sing Chuen_US
dc.contributor.authorShinn Jang Hwangen_US
dc.contributor.authorPan Chyr Yangen_US
dc.contributor.authorPrasert Thongcharoenen_US
dc.contributor.authorFong S. Limen_US
dc.contributor.authorMamadou Draméen_US
dc.contributor.authorKarl Walravensen_US
dc.contributor.authorFrançois Romanen_US
dc.contributor.otherGlaxoSmithKline Pharmaceuticals SAen_US
dc.contributor.otherQueen Mary Hospital Hong Kongen_US
dc.contributor.otherNational Yang-Ming University Taiwanen_US
dc.contributor.otherNational Taiwan University College of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Healthcare Group Polyclinics, Singaporeen_US
dc.contributor.otherGlaxoSmithKline, USAen_US
dc.date.accessioned2018-11-09T02:38:49Z-
dc.date.available2018-11-09T02:38:49Z-
dc.date.issued2014-03-15en_US
dc.identifier.citationBMC Infectious Diseases. Vol.14, No.1 (2014)en_US
dc.identifier.issn14712334en_US
dc.identifier.other2-s2.0-84899098483en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899098483&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/34267-
dc.description.abstractBackground: The pandemic potential of avian influenza A/H5N1 should not be overlooked, and the continued development of vaccines against these highly pathogenic viruses is a public health priority.Methods: This open-label extension booster study followed a Phase III study of 1206 adults who had received two 3.75 μg doses of primary AS03A-adjuvanted or non-adjuvanted H5N1 split-virus vaccine (A/Vietnam/1194/2004; clade 1) (NCT00449670). The aim of the extension study was to evaluate different timings for heterologous AS03A-adjuvanted booster vaccination (A/Indonesia/5/2005; clade 2.1) given at Month 6, 12, or 36 post-primary vaccination. Immunogenicity was assessed 21 days after each booster vaccination and the persistence of immune responses against the primary vaccine strain (A/Vietnam) and the booster strain (A/Indonesia) was evaluated up to Month 48 post-primary vaccination. Reactogenicity and safety were also assessed.Results: After booster vaccination given at Month 6, HI antibody responses to primary vaccine, and booster vaccine strains were markedly higher with one dose of AS03A-H5N1 booster vaccine in the AS03A-adjuvanted primary vaccine group compared with two doses of booster vaccine in the non-adjuvanted primary vaccine group. HI antibody responses were robust against the primary and booster vaccine strains 21 days after boosting at Month 12 or 36. At Month 48, in subjects boosted at Month 6, 12, or 36, HI antibody titers of ≥1:40 against the booster strain persisted in 39.2%, 61.2%, and 95.6% of subjects, respectively. Neutralizing antibody responses and cell-mediated immune responses also showed that AS03A-H5N1 heterologous booster vaccination elicited robust immune responses within 21 days of boosting at Month 6, 12, or 36 post-primary vaccination. The booster vaccine was well tolerated, and no safety concerns were raised.Conclusions: In Asian adults primed with two doses of AS03A-adjuvanted H5N1 pandemic influenza vaccine, strong cross-clade anamnestic antibody responses were observed after one dose of AS03A-H5N1 heterologous booster vaccine given at Month 6, 12, or 36 after priming, suggesting that AS03A-adjuvanted H5N1 vaccines may provide highly flexible prime-boost schedules. Although immunogenicity decreased with time, vaccinated populations could potentially be protected for up to three years after vaccination, which is likely to far exceed the peak of the a pandemic. © 2014 Gillard et al.; licensee BioMed Central Ltd.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899098483&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleLong-term booster schedules with AS03<inf>A</inf>-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adultsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1186/1471-2334-14-142en_US
Appears in Collections:Scopus 2011-2015

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