Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: The International Criteria for Behçet's Disease (ICBD): A collaborative study of 27 countries on the sensitivity and specificity of the new criteria
Authors: F. Davatchi
S. Assaad-Khalil
K. T. Calamia
J. E. Crook
B. Sadeghi-Abdollahi
M. Schirmer
T. Tzellos
C. C. Zouboulis
M. Akhlagi
A. Al-Dalaan
Z. S. Alekberova
A. A. Ali
A. Altenburg
E. Arromdee
M. Baltaci
M. Bastos
S. Benamour
I. Ben Ghorbel
A. Boyvat
L. Carvalho
W. Chen
E. Ben-Chetrit
C. Chams-Davatchi
J. A. Correia
J. Crespo
C. Dias
Y. Dong
F. Paixão-Duarte
K. Elmuntaser
A. V. Elonakov
J. Graña Gil
A. A. Haghdoost
R. M. Hayani
H. Houman
A. R. Isayeva
A. R. Jamshidi
P. Kaklamanis
A. Kumar
A. Kyrgidis
W. Madanat
A. Nadji
K. Namba
S. Ohno
I. Olivieri
J. Vaz Patto
N. Pipitone
M. V. De Queiroz
F. Ramos
C. Resende
C. M. Rosa
C. Salvarani
M. J. Serra
F. Shahram
H. Shams
K. E. Sharquie
M. Sliti-Khanfir
T. Tribolet De Abreu
C. Vasconcelos
J. Vedes
B. Wechsler
Y. K. Cheng
Z. Zhang
N. Ziaei
Tehran University of Medical Sciences
Alexandria Medical School
Mayo Clinic in Jacksonville, Florida
Medizinische Universitat Innsbruck
Stadtisches Klinikum Dessau
German Registry of Adamantiades-Behçet's Disease
King Saud University
V.A. Nasonova Research Institute of Rheumatology
The Aga Khan University Hospital
Mahidol University
Hospital São Teotónio
Centre Hospitalier Universitaire Ibn-Rochd
Department of Internal Medicine
Ankara Universitesi
Hospital Geral de Santo Antonio
Chang Gung University
Hadassah University Medical Centre
Centro Hospitalar e Universitario de Coimbra
Sao Joao Hospital
Peking Union Medical College
Fernando da Fonseca Hospital
Kadisia Clinic
Complejo Hospitalario Universitario Juan Canalejo
University of Baghdad
Azerbaycan Tibb Universiteti
Medical Center
All India Institute of Medical Sciences, New Delhi
Jordan Hospital
Hokkaido University School of Medicine
Potenza and Madonna Delle Grazie Hospital
Instituto Portugues de Reumatologia
Azienda Ospedaliera Santa Maria Nuova di Reggio Emilia
Santa Maria Hospital, Lisbon
University of Lisbon Faculty of Medicine, Institute of Molecular Medicine
Santo António dos Capuchos Hospital
Hospital do Espirito Santo
Hospital Sousa Martins
Hopital Universitaire Pitie Salpetriere
Gleneagles Hospital
Peking University
Keywords: Medicine
Issue Date: 1-Mar-2014
Citation: Journal of the European Academy of Dermatology and Venereology. Vol.28, No.3 (2014), 338-347
Abstract: Objective Behçet's disease (BD) is a chronic, relapsing, inflammatory vascular disease with no pathognomonic test. Low sensitivity of the currently applied International Study Group (ISG) clinical diagnostic criteria led to their reassessment. Methods An International Team for the Revision of the International Criteria for BD (from 27 countries) submitted data from 2556 clinically diagnosed BD patients and 1163 controls with BD-mimicking diseases or presenting at least one major BD sign. These were randomly divided into training and validation sets. Logistic regression, 'leave-one-country-out' cross-validation and clinical judgement were employed to develop new International Criteria for BD (ICBD) with the training data. Existing and new criteria were tested for their performance in the validation set. Results For the ICBD, ocular lesions, oral aphthosis and genital aphthosis are each assigned 2 points, while skin lesions, central nervous system involvement and vascular manifestations 1 point each. The pathergy test, when used, was assigned 1 point. A patient scoring ≥4 points is classified as having BD. In the training set, 93.9% sensitivity and 92.1% specificity were assessed compared with 81.2% sensitivity and 95.9% specificity for the ISG criteria. In the validation set, ICBD demonstrated an unbiased estimate of sensitivity of 94.8% (95% CI: 93.4-95.9%), considerably higher than that of the ISG criteria (85.0%). Specificity (90.5%, 95% CI: 87.9-92.8%) was lower than that of the ISG-criteria (96.0%), yet still reasonably high. For countries with at least 90%-of-cases and controls having a pathergy test, adding 1 point for pathergy test increased the estimate of sensitivity from 95.5% to 98.5%, while barely reducing specificity from 92.1% to 91.6%. Conclusion The new proposed criteria derived from multinational data exhibits much improved sensitivity over the ISG criteria while maintaining reasonable specificity. It is proposed that the ICBD criteria to be adopted both as a guide for diagnosis and classification of BD. © 2013 European Academy of Dermatology and Venereology.
ISSN: 14683083
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.