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Title: Lack of association between BSG polymorphisms and cerebral malaria
Authors: Izumi Naka
Jintana Patarapotikul
Hathairad Hananantachai
Jun Ohashi
University of Tsukuba
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2014
Citation: Japanese Journal of Infectious Diseases. Vol.67, No.6 (2014), 432-435
Abstract: © National Institute of Health. All Rights Reserved. The Okablood group antigen basigin (BSG or CD147) is an erythrocyte receptor for the PfRh5 protein from Plasmodium falciparum. A recent study has shown that the PfRh5-BSG interaction is essential for erythrocyte invasion by P. falciparum. In this study, 6 SNPs in the BSG gene were investigated in 312 adult patients with P. falciparum malaria (109 cerebral malaria and 203 mild malaria patients) living in northwest Thailand. To examine the association between BSG SNPs and cerebral malaria, the allele and haplotype frequencies were compared in cerebral and mild malaria patients. Non-synonymous SNPs were not assessed in the association analysis. The results showed that common BSG polymorphisms and haplotypes were not significantly associated with cerebral malaria. In conclusion, common SNPs in BSG do not influence the risk of cerebral malaria in the Thai population.
ISSN: 18842836
Appears in Collections:Scopus 2011-2015

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