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dc.contributor.authorSatoshi Takeuchien_US
dc.contributor.authorBenjapa Khiewvanen_US
dc.contributor.authorPatricia S. Foxen_US
dc.contributor.authorStephen G. Swisheren_US
dc.contributor.authorEric M. Rohrenen_US
dc.contributor.authorRoland L. Bassetten_US
dc.contributor.authorHomer A. Macapinlacen_US
dc.contributor.otherUniversity of Texas MD Anderson Cancer Centeren_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationEuropean Journal of Nuclear Medicine and Molecular Imaging. Vol.41, No.5 (2014), 906-914en_US
dc.description.abstractPurpose: Our objective was to determine the impact of initial18F-FDG PET/CT (PET/CT) staging on clinical stage and the management plan and the prognostic value of PET/CT in patients with non-small-cell lung cancer (NSCLC). Methods: We retrospectively reviewed the records of 592 patients with NSCLC who were referred to The University of Texas MD Anderson Cancer Center during 2002/2011 and had both PET/CT and conventional CT for initial staging. Clinical stages and management plans were compared between PET/CT and CT. The impact of PET/CT on management plans was considered medium/high when PET/CT changed the planned treatment modality or treatment intent. PET/CT and CT stages were compared with all-cause mortality and survival rates. We also assessed potential prognostic factors for progression-free survival (PFS) and overall survival (OS). Results: PET/CT changed the stage in 170 patients (28.7 %; 16.4 % upstaged, 12.3 % downstaged). PET/CT had a medium/high impact on the management plan in 220 patients (37.2 %). PFS and OS were significantly worse in patients with upstaged disease than in patients with no change in stage (median PFS 29.0 vs. 53.8 months, P<0.001; median OS:64.7 vs. 115.9 months, P=0.006). PFS and OS were significantly worse in patients with medium/high impact of PET/CT than in patients with no/low impact of PET/CT (median PFS 24.7 vs. 60.6 months, P<0.001; median OS 64.7 vs. 115.9 months, P<0.001). In multivariate analysis, a medium/high impact of PET/CT was an independent predictor of worse PFS (hazard ratio, HR, 1.73; 95 % CI 1.30 - 2.29; P=0.0002) and OS (HR 1.84; 95 % CI 1.26 - 2.69; P=0.002). Conclusion: Initial PET/CT staging not only impacts stage and management plan but also has prognostic value. © 2014 Springer-Verlag Berlin Heidelberg.en_US
dc.rightsMahidol Universityen_US
dc.titleImpact of initial PET/CT staging in terms of clinical stage, management plan, and prognosis in 592 patients with non-small-cell lung canceren_US
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