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Title: Meta-analysis of hypercoagulability genetic polymorphisms in perthes disease
Authors: Patarawan Woratanarat
Charnwit Thaveeratitharm
Thira Woratanarat
Chanika Angsanuntsukh
John Attia
Ammarin Thakkinstian
Mahidol University
Chulalongkorn University
University of Newcastle, Australia
Keywords: Medicine
Issue Date: 1-Jan-2014
Citation: Journal of Orthopaedic Research. Vol.32, No.1 (2014), 1-7
Abstract: Perthes disease is an osteonecrosis of the femoral epiphysis with unclear etiology. This study aimed to systematically review the association between genetic determinants of hypercoagulability (Factor V Leiden, prothrombin II, and methylenetetrahydrofolate reductase; MTHFR) and Perthes disease. PubMed and Scopus searched from inception to January 2012, data extraction and quality assessment were performed. The odds ratio (OR) for the allele effect was pooled, and heterogeneity and publication bias were assessed. Twelve case-control studies met inclusion criteria and had sufficient data for extraction. There were 824 cases and 2,033 controls with a mean age range of 6.1-14.7 years. The prevalence of the minor allele in controls was 0.015 (95% confidence interval (CI): 0.008, 0.023), 0.012 (95% CI: 0.008, 0.017), and 0.105 (95% CI: 0.044, 0.167) for factor V Leiden, prothrombin II, and MTHFR, respectively. The factor V Leiden allele increased the risk of Perthes with a pooled OR of 3.10 (95% CI: 1.68, 5.72), while prothrombin II and MTHFR had non-significantly pooled OR 1.48 (95% CI: 0.71, 3.08), and 0.97 (95% CI: 0.72, 1.30), respectively. The factor V Leiden mutation is significantly related to Perthes disease, and its screening in at-risk children might be useful in the future. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
ISSN: 1554527X
Appears in Collections:Scopus 2011-2015

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