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Title: 'Suspicious for papillary thyroid carcinoma' before and after the bethesda system for reporting thyroid cytopathology: Impact of standardized terminology
Authors: Matthew T. Olson
Thiraphon Boonyaarunnate
Aysegul Aksoy Atlinboga
Syed Z. Ali
Johns Hopkins Hospital
Mahidol University
Ankara University, Faculty of Medicine
Keywords: Medicine
Issue Date: 1-Jan-2014
Citation: Acta Cytologica. Vol.58, No.1 (2014), 15-22
Abstract: Background: The high-risk 'suspicious for papillary thyroid carcinoma' (SPTC) is a clinically relevant diagnosis in the cytological interpretation of thyroid aspirates. While The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has provided invaluable terminology standardization, a performance comparison for this diagnostic category has not been performed. Therefore, this study evaluates the SPTC diagnosis before and after the introduction of TBSRTC in a large meta-analysis and at a single institution. Materials and Methods: The meta-analysis analyzed publications of SPTC or similar diagnoses before and after the introduction of TBSRTC. Similarly our own institutional experience was analyzed for the 8 years surrounding the introduction of TBSRTC. A correlation of the cytopathology and surgical pathology diagnoses was performed. Results: The introduction of TBSRTC coincided with a significant decrease in the fraction of cases called SPTC in the meta-analysis (4.5-3.1%, p < 0.00001) and in the institutional review (1.7-0.9%, p = 0.005). Meanwhile, the malignancy risk for those cases increased significantly in the meta-analysis from 62.5 to 80.5% (p < 0.00001) and trended upwards in the institutional review from 69 to 79% (p = 0.4). The follow-up rate was similar in both time periods in the meta-analysis and the institutional review. Conclusions: The introduction of TBSRTC coincided with a decrease in the fraction of cases called SPTC and an increase in the malignancy risk associated with that diagnosis. © 2013 S. Karger AG, Basel.
ISSN: 19382650
Appears in Collections:Scopus 2011-2015

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