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dc.contributor.authorNicole Stoesseren_US
dc.contributor.authorSivilay Xayaheuangen_US
dc.contributor.authorManivanh Vongsouvathen_US
dc.contributor.authorKoukeo Phommasoneen_US
dc.contributor.authorIvo Elliotten_US
dc.contributor.authorCarlos Del Ojo Eliasen_US
dc.contributor.authorDerrick W. Crooken_US
dc.contributor.authorPaul N. Newtonen_US
dc.contributor.authorYves Buissonen_US
dc.contributor.authorSue J. Leeen_US
dc.contributor.authorDavid A.B. Danceen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherInstitut de la Francophonie pour la Médecine Tropicaleen_US
dc.contributor.otherMahosot Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-11-09T03:01:16Z-
dc.date.available2018-11-09T03:01:16Z-
dc.date.issued2014-01-01en_US
dc.identifier.citationJournal of Antimicrobial Chemotherapy. Vol.70, No.6 (2014), 1893-1897en_US
dc.identifier.issn14602091en_US
dc.identifier.issn03057453en_US
dc.identifier.other2-s2.0-84930513513en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930513513&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/34770-
dc.description.abstract© The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. Objectives: Intestinal carriage constitutes an important reservoir of antimicrobial-resistant bacteria, with some of the highest rates reported from Asia. Antibiotic resistance has been little studied in Laos, where some antibiotics are available without restriction, but others such as carbapenems are not available. Patients and methods: We collected stools from 397 healthy children in 12 randomly selected pre-school childcare facilities in and around Vientiane. Colonization with ESBL-producing Enterobacteriaceae (ESBLE) and carbapenemase-producing Enterobacteriaceae (CPE) was detected using a disc diffusion screening test and ESBLE were characterized using WGS. Risk factor data were collected by questionnaire. Results: Ninety-two children (23%) were colonized with ESBLE, mainly Escherichia coli carrying bla<inf>CTX-M</inf> and Klebsiella pneumoniae carrying bla<inf>SHV</inf> or bla<inf>CTX-M</inf>, which were frequently resistant to multiple antibiotic classes. Although residence in Vientiane Capital, foreign travel, higher maternal level of education, antibiotic use in the preceding 3 months and attending a childcare facility with a 'good' level of hygiene were all associated with ESBLE colonization on univariable analysis, a significant association remained only for antibiotic use when a stepwise approach was used with a multivariate random-effects model. WGS analysis suggested transmission in both childcare facilities and community settings. Conclusions: The high prevalence of paediatric colonization with ESBLE in Laos, one of the highest reported in Asia, is probably the result of inappropriate antibiotic use. Paediatric colonization with CPE was not identified in this study, but it is important to continue to monitor the spread of antibiotic-resistant Enterobacteriaceae in Laos.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930513513&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleColonization with Enterobacteriaceae producing ESBLs in children attending pre-school childcare facilities in the Lao People's Democratic Republicen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1093/jac/dkv021en_US
Appears in Collections:Scopus 2011-2015

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