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Title: Microevolution of Burkholderia pseudomallei during an acute infection
Authors: Direk Limmathurotsakul
Matthew T.G. Holden
Paul Coupland
Erin P. Price
Narisara Chantratita
Vanaporn Wuthiekanun
Premjit Amornchai
Julian Parkhill
Sharon J. Peacock
Mahidol University
Wellcome Trust Sanger Institute
Menzies School of Health Research
University of Cambridge
University of St Andrews, School of Medicine
Keywords: Medicine
Issue Date: 1-Jan-2014
Citation: Journal of Clinical Microbiology. Vol.52, No.9 (2014), 3418-3421
Abstract: We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread. Copyright © 2014 Limmathurotsakul et al.
ISSN: 1098660X
Appears in Collections:Scopus 2011-2015

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