Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/34799
Title: Worldwide dissemination of acquired carbapenem-hydrolysing class D β-lactamases in Acinetobacter spp. other than Acinetobacter baumannii
Authors: Esther Zander
Ana Fernández-González
Xenia Schleicher
Cathrin Dammhayn
Witchuda Kamolvit
Harald Seifert
Paul G. Higgins
University of Cologne
Universidade da Coruña
University of Queensland, Centre for Clinical Research
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2014
Citation: International Journal of Antimicrobial Agents. Vol.43, No.4 (2014), 375-377
Abstract: The aim of this study was to identify acquired OXA-type carbapenemases in Acinetobacter spp. other than Acinetobacter baumannii. From a total of 453 carbapenem-susceptible and -resistant Acinetobacter isolates collected worldwide, 23 were positive for blaOXAgenes by multiplex PCR. These isolates were identified as Acinetobacter pittii (n = 18), Acinetobacter nosocomialis (n = 2), Acinetobacter junii (n = 1) and Acinetobacter genomic species 14TU/13BJ (n = 2). The blaOXAgenes and associated insertion sequence (IS) elements were sequenced by primer walking. In 11 of these isolates, sequencing of the PCR products revealed that they were false-positive for blaOXA. The remaining 12 isolates, originating from Europe, Asia, South America, North America and South Africa, harboured OXA-23 (n = 4), OXA-58 (n = 5), OXA-40-like (n = 1) and OXA-143-like (n = 1); one A. pittii isolate harboured both OXA-23 and OXA-58. IS elements were associated with blaOXAin 10 isolates. OXA multiplex PCR showed a high degree of false-positive results (47.8%), indicating that detection of blaOXAin non-baumannii Acinetobacter spp. should be confirmed using additional methods. © 2014 Elsevier B.V. and the International Society of Chemotherapy.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897985943&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/34799
ISSN: 18727913
09248579
Appears in Collections:Scopus 2011-2015

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