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|Title:||Plasmodium falciparum founder populations in western Cambodia have reduced artemisinin sensitivity in vitro|
Rick M. Fairhurst
National Institute of Allergy and Infectious Diseases
Institut Pasteur du Cambodge
National Center for Parasitology, Entomology and Malaria Control
University of Oxford
Wellcome Trust Sanger Institute
|Keywords:||Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Antimicrobial Agents and Chemotherapy. Vol.58, No.8 (2014), 4935-4937|
|Abstract:||Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life. We recently defined three parasite founder populations with long half-lives in Pursat, western Cambodia, where reduced ART sensitivity is prevalent. Using the ring-stage survival assay, we show that these founder populations have reduced ART sensitivity in vitro at the early ring stage of parasite development and that a genetically admixed population contains subsets of parasites with normal or reduced ART sensitivity. Copyright © 2014, American Society for Microbiology. All Rights Reserved.|
|Appears in Collections:||Scopus 2011-2015|
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