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Title: Plasmodium falciparum founder populations in western Cambodia have reduced artemisinin sensitivity in vitro
Authors: Chanaki Amaratunga
Benoit Witkowski
Dalin Dek
Vorleak Try
Nimol Khim
Olivo Miotto
Didier Ménard
Rick M. Fairhurst
National Institute of Allergy and Infectious Diseases
Institut Pasteur du Cambodge
National Center for Parasitology, Entomology and Malaria Control
University of Oxford
Mahidol University
Wellcome Trust Sanger Institute
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2014
Citation: Antimicrobial Agents and Chemotherapy. Vol.58, No.8 (2014), 4935-4937
Abstract: Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life. We recently defined three parasite founder populations with long half-lives in Pursat, western Cambodia, where reduced ART sensitivity is prevalent. Using the ring-stage survival assay, we show that these founder populations have reduced ART sensitivity in vitro at the early ring stage of parasite development and that a genetically admixed population contains subsets of parasites with normal or reduced ART sensitivity. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
ISSN: 10986596
Appears in Collections:Scopus 2011-2015

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