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Title: Unmet treatment needs of gastroesophageal reflux disease in Asia: Gastroesophageal reflux disease in Asia Pacific Survey
Authors: Khean Lee Goh
Myung Gyu Choi
William Ping I. Hsu
Hoon Jai Chun
Varocha Mahachai
Udom Kachintorn
Somchai Leelakusolvong
Nayoung Kim
Abdul Aziz Rani
Benjamin Cy Wong
Justin Wu
Cheng Tang Chiu
Romeo Chu
Vikram Shetty
Joseph C. Bocobo
Melchor M. Chan
Jaw Town Lin
University of Malaya
The Catholic University of Korea
Korea University, College of Medicine
Seoul National University Bundang Hospital
Veterans General Hospital-Kaohsiung Taiwan
Chang Gung Memorial Hospital
Fu Jen Catholic University
Chulalongkorn University
Mahidol University
Universitas Indonesia
The University of Hong Kong
Chinese University of Hong Kong
Takeda Pharmaceuticals (Asia Pacific) Pte Ltd
St. Luke's College of Medicine-William H. Quasha Memorial
University of Santo Tomas Hospital
Keywords: Medicine
Issue Date: 1-Jan-2014
Citation: Journal of Gastroenterology and Hepatology (Australia). Vol.29, No.12 (2014), 1969-1975
Abstract: © 2014 Wiley Publishing Asia Pty Ltd and Journal of Gastroenterology and Hepatology Foundation. Background and Aim: Data on patient satisfaction with proton pump inhibitor (PPI) therapy for gastroesophageal reflux disease (GERD) are scarce in Asia. The perspectives of Asian patients with GERD and their satisfaction with PPI therapy were investigated. Methods: The GERD in Asia Pacific Survey (GAPS) was conducted from December 2011 to March 2012. Patients aged 21-55 years with self-reported doctor-diagnosed GERD, who had experienced symptoms in the previous 12 months, and were currently taking PPIs were enrolled. After a pilot study, a questionnaire was completed by respondents from six Asian countries during face-to-face interviews. Results: A total of 450 patients with GERD participated in the GAPS. Although the respondents generally complied with treatment, response to therapy was only partially successful. Most respondents indicated that PPIs eliminated pain (72%), took effect within 30min (76%), provided sustained relief (73%), and provided nocturnal relief (77%). However, 45% of respondents reported limited improvement in nocturnal symptoms, and 49% continued to take adjunctive therapy to manage their symptoms. After treatment, respondent's "well-being" had improved. However, GERD still had a negative impact on well-being for 76% of respondents after treatment, compared with 94% before treatment. Conclusions: Asian patients reported a negative impact of GERD on their daily lives. Many respondents continued to experience symptoms despite reporting good compliance with PPI therapy, emphasizing the shortcomings of currently available therapy for GERD. This survey is the first to highlight Asian patients' perspectives of GERD and PPI therapy, and provides a platform for further evaluation.
ISSN: 14401746
Appears in Collections:Scopus 2011-2015

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