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dc.contributor.authorJohn A. Lawsonen_US
dc.contributor.authorChi Fung Chanen_US
dc.contributor.authorChing Shiang Chien_US
dc.contributor.authorPi Chuan Fanen_US
dc.contributor.authorHeung Dong Kimen_US
dc.contributor.authorKi Joong Kimen_US
dc.contributor.authorSurachai Likasitwatanakulen_US
dc.contributor.authorMarilyn Ortizen_US
dc.contributor.authorKate Rineyen_US
dc.contributor.authorStacey Kiat Hong Tayen_US
dc.contributor.authorChee Kian Thamen_US
dc.contributor.otherUniversity of New South Wales (UNSW) Australiaen_US
dc.contributor.otherThe University of Hong Kongen_US
dc.contributor.otherTungs' Taichung MetroHarbor Hospitalen_US
dc.contributor.otherNational Taiwan University Hospitalen_US
dc.contributor.otherYonsei University College of Medicineen_US
dc.contributor.otherSeoul National Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPhilippine Children's Medical Centeren_US
dc.contributor.otherSt. Luke's Medical Center Quezon Cityen_US
dc.contributor.otherMater Children's Hospitalen_US
dc.contributor.otherYong Loo Lin School of Medicineen_US
dc.contributor.otherNational University Health Systemen_US
dc.contributor.otherNational Cancer Centre, Singaporeen_US
dc.date.accessioned2018-11-09T03:06:44Z-
dc.date.available2018-11-09T03:06:44Z-
dc.date.issued2014-01-01en_US
dc.identifier.citationJournal of Clinical Neuroscience. Vol.21, No.7 (2014), 1180-1187en_US
dc.identifier.issn15322653en_US
dc.identifier.issn09675868en_US
dc.identifier.other2-s2.0-84901229579en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901229579&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/34877-
dc.description.abstractTuberous sclerosis complex (TSC) is a multisystem genetic disorder, with heterogeneous manifestations that pose major diagnostic and management challenges and incur considerable chronic disease burden on patients, their caregivers and healthcare systems. This survey of clinical practice in the Asia-Pacific region highlights priorities for improving TSC management in the region. The prevalence of TSC in non-Caucasians is uncertain and more data are needed to assess its impact and health-economic burden. There are unmet needs for access to genetic testing and earlier diagnosis and intervention. TSC management is multidisciplinary and largely based on experience, backed by international guidelines; however, physicians in the Asia-Pacific region feel isolated and lack local or regional guidance and support structures to implement best-practice. Raising awareness of TSC and increasing trans-regional collaboration are particular priorities. Understanding of TSC pathophysiology has enabled the development of targeted therapies. Encouraging data indicate that mammalian target of rapamycin (mTOR) inhibitors can ameliorate TSC-related lesions and may potentially change the treatment paradigm. Ultimately, improving outcomes for TSC patients in the region requires greater collaboration and a holistic, patient-focused, continuum of care that is maintained through the transition from pediatric to adult care. © 2013 Elsevier Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901229579&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectNeuroscienceen_US
dc.titleManaging tuberous sclerosis in the Asia-Pacific region: Refining practice and the role of targeted therapyen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.jocn.2013.06.029en_US
Appears in Collections:Scopus 2011-2015

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