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Title: Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis
Authors: Giovanni Musso
Roberto Gambino
James H. Tabibian
Mattias Ekstedt
Stergios Kechagias
Masahide Hamaguchi
Rolf Hultcrantz
Hannes Hagström
Seung Kew Yoon
Phunchai Charatcharoenwitthaya
Jacob George
Francisco Barrera
Svanhildur Haflidadóttir
Einar Stefan Björnsson
Matthew J. Armstrong
Laurence J. Hopkins
Xin Gao
Sven Francque
An Verrijken
Yusuf Yilmaz
Keith D. Lindor
Michael Charlton
Robin Haring
Markus M. Lerch
Rainer Rettig
Henry Völzke
Seungho Ryu
Guolin Li
Linda L. Wong
Mariana Machado
Helena Cortez-Pinto
Kohichiroh Yasui
Maurizio Cassader
Universita degli Studi di Torino
Mayo Clinic
Linkopings universitet
Osaka University
Karolinska University Hospital
The Catholic University of Korea, College of Medicine
Mahidol University
The University of Sydney
Landspitali University Hospital
University of Birmingham
Fudan University
Universitair Ziekenhuis Antwerpen
Marmara Universitesi
Ernst-Moritz-Arndt-Universitat Greifswald
University Medicine Greifswald
Sungkyunkwan University
Hunan Normal University
University of Hawaii at Manoa John A. Burns School of Medicine
Santa Maria Hospital, Lisbon
Kyoto Prefectural University of Medicine
Keywords: Medicine
Issue Date: 1-Jan-2014
Citation: PLoS Medicine. Vol.11, No.7 (2014)
Abstract: Background:Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associated with the presence and severity of CKD.Methods and Findings:English and non-English articles from international online databases from 1980 through January 31, 2014 were searched. Observational studies assessing NAFLD by histology, imaging, or biochemistry and defining CKD as either estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2or proteinuria were included. Two reviewers extracted studies independently and in duplicate. Individual participant data (IPD) were solicited from all selected studies. Studies providing IPD were combined with studies providing only aggregate data with the two-stage method. Main outcomes were pooled using random-effects models. Sensitivity and subgroup analyses were used to explore sources of heterogeneity and the effect of potential confounders. The influences of age, whole-body/abdominal obesity, homeostasis model of insulin resistance (HOMA-IR), and duration of follow-up on effect estimates were assessed by meta-regression. Thirty-three studies (63,902 participants, 16 population-based and 17 hospital-based, 20 cross-sectional, and 13 longitudinal) were included. For 20 studies (61% of included studies, 11 cross-sectional and nine longitudinal, 29,282 participants), we obtained IPD. NAFLD was associated with an increased risk of prevalent (odds ratio [OR] 2.12, 95% CI 1.69-2.66) and incident (hazard ratio [HR] 1.79, 95% CI 1.65-1.95) CKD. Non-alcoholic steatohepatitis (NASH) was associated with a higher prevalence (OR 2.53, 95% CI 1.58-4.05) and incidence (HR 2.12, 95% CI 1.42-3.17) of CKD than simple steatosis. Advanced fibrosis was associated with a higher prevalence (OR 5.20, 95% CI 3.14-8.61) and incidence (HR 3.29, 95% CI 2.30-4.71) of CKD than non-advanced fibrosis. In all analyses, the magnitude and direction of effects remained unaffected by diabetes status, after adjustment for other risk factors, and in other subgroup and meta-regression analyses. In cross-sectional and longitudinal studies, the severity of NAFLD was positively associated with CKD stages. Limitations of analysis are the relatively small size of studies utilizing liver histology and the suboptimal sensitivity of ultrasound and biochemistry for NAFLD detection in population-based studies.Conclusion:The presence and severity of NAFLD are associated with an increased risk and severity of CKD.Please see later in the article for the Editors' Summary. © 2014 Musso et al.
ISSN: 15491676
Appears in Collections:Scopus 2011-2015

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