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Title: Preliminary pharmaceutical development of antimalarial-antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas
Authors: Alexandra Gaubert
Tina Kauss
Mathieu Marchivie
Boubakar B. Ba
Martine Lembege
Fawaz Fawaz
Jean Michel Boiron
Xavier Lafarge
Niklas Lindegardh
Jean Louis Fabre
Nicholas J. White
Piero L. Olliaro
Pascal Millet
Karen Gaudin
Developpements Analytiques et Pharmaceutiques Appliques aux Maladies Negligees et Aux Contrefacons
Universite de Bordeaux
Etablissement Francais du Sang
Mahidol University
OTECI (Office Technique d'Etude et de Coopération Internationale)
Nuffield Department of Clinical Medicine
Organisation Mondiale de la Sante
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-2014
Citation: International Journal of Pharmaceutics. Vol.468, No.1-2 (2014), 55-63
Abstract: Artemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas. The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective against both malaria and bacterial infections. Analytical and pharmacotechnical development, followed by in vitro and in vivo evaluation, were conducted for various AMAZ coformulations. Of the formulations tested, stability was highest for dry solid forms and bioavailability for hard gelatin capsules; AM release from AMAZ rectodispersible tablet was suboptimal due to a modification of its micro-crystalline structure. © 2014 The Authors.
ISSN: 18733476
Appears in Collections:Scopus 2011-2015

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