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Title: Bipolamides A and B, triene amides isolated from the endophytic fungus Bipolaris sp. MU34
Authors: Ratklao Siriwach
Hiroshi Kinoshita
Shigeru Kitani
Yasuhiro Igarashi
Kanokthip Pansuksan
Watanalai Panbangred
Takuya Nihira
Osaka University
Toyama Prefectural University
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Feb-2014
Citation: Journal of Antibiotics. Vol.67, No.2 (2014), 167-170
Abstract: As a result of the continued screening for new metabolites produced by endophytic fungi from Thai medicinal plants, two new triene fatty acid amides, bipolamides A (1) and B (2), were discovered from the endophytic fungus Bipolaris sp. MU34. The structures of all of the isolated compounds were elucidated on the basis of the spectroscopic data of NMR and MS. An antimicrobial assay revealed that bipolamide B (2) had moderate antifungal activity against Cladosporium cladosporioides FERMS-9, Cladosporium cucumerinum NBRC 6370, Saccharomyces cerevisiae ATCC 9804, Aspergillus niger ATCC 6275 and Rhisopus oryzae ATCC 10404, with Minimum inhibitory concentration (MIC) values of 16, 32, 32, 64 and 64 μg ml -1, respectively. © 2014 Japan Antibiotics Research Association.
ISSN: 18811469
Appears in Collections:Scopus 2011-2015

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