Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPeipei Lien_US
dc.contributor.authorHua Xingen_US
dc.contributor.authorZhenjun Zhaoen_US
dc.contributor.authorZhaoqing Yangen_US
dc.contributor.authorYaming Caoen_US
dc.contributor.authorWenli Lien_US
dc.contributor.authorGuiyun Yanen_US
dc.contributor.authorJetsumon Sattabongkoten_US
dc.contributor.authorLiwang Cuien_US
dc.contributor.authorQi Fanen_US
dc.contributor.otherDalian Institute of Biotechnologyen_US
dc.contributor.otherDalian University of Technologyen_US
dc.contributor.otherKunming Medical Universityen_US
dc.contributor.otherChina Medical University Shenyangen_US
dc.contributor.otherUniversity of California, Irvineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPennsylvania State Universityen_US
dc.identifier.citationActa Tropica. Vol.152, (2015), 26-31en_US
dc.description.abstract© 2015 Elsevier B.V. Deletion of the Plasmodium falciparum histidine-rich protein 2 (pfhrp2) gene may affect the performance of PfHRP2-based rapid diagnostic tests (RDTs). Here we investigated the genetic diversity of the pfhrp2 gene in clinical parasite isolates collected in recent years from the China-Myanmar border area. Deletion of pfhrp2 has been identified in 4 out of 97 parasite isolates. Sequencing of the pfhrp2 exon2 from 67 isolates revealed a high level of genetic diversity in pfhrp2, which is reflected in the presence of many repeat types and their variants, as well as variable copy numbers and different arrangements of these repeats in parasite isolates. In addition, we observed pfhrp3 deletion in three of the four parasites harboring pfhrp2 deletion, suggesting of double deletions of both genes in these three isolates. Analysis of two cases, which were P. falciparum-positive by microscopy and PCR but failed by two PfHRP2-based RDTs, did not find pfhrp2 deletion. Further correlational studies of pfhrp2 polymorphisms with detection sensitivity are needed to identify factors influencing the performance of RDTs in malaria-endemic areas.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleGenetic diversity of Plasmodium falciparum histidine-rich protein 2 in the China-Myanmar border areaen_US
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.