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Title: Monte carlo cellular automata simulation of receptor trafficking in cell signal transduction: Tracking dimer and oligomer formation
Authors: Chontita Rattanakul
Yongwimon Lenbury
Mahidol University
South Carolina Commission on Higher Education
Keywords: Agricultural and Biological Sciences
Issue Date: 15-Nov-2015
Citation: Kasetsart Journal - Natural Science. Vol.49, No.6 (2015), 1036-1046
Abstract: © 2015, Kasetsart University. All rights reserved. A cellular automata (CA) model of the signal transduction pathway mediated by calcium sensing (CaS) receptors was constructed to investigate the effects of different fractions of healthy (functional) and defective receptors. Receptor trafficking was allowed to take place leading to dimerization and oligomerization which exerted a positive impact on the receptor binding affinity. Snapshots of receptor trafficking and distribution over the cell membrane simulated by the CA model were compared with the no-trafficking case.
ISSN: 00755192
Appears in Collections:Scopus 2011-2015

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