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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/35119
Title: A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings
Authors: Hui Xia
Qiang Fang
Kulachart Jangpatarapongsa
Tao Zhiyong
Liwang Cui
Baiqing Li
Rachanee Udomsangpetch
Bengbu Medical College
Mahidol University
Pennsylvania State University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 6-Aug-2015
Citation: EXCLI Journal. Vol.14, (2015), 926-934
Abstract: © 2015, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved. The mechanisms of cellular and humoral immune responses against P. vivax parasite remain poorly understood. Several malaria immunological studies have been conducted in endemic regions where both P. falciparum and P. vivax parasites co-exist. In this study, a comparative analysis of immunity to Plasmodium vivax antigens in different geography and incidence of Plasmodium spp. infection was performed. We characterised antibodies against two P. vivax antigens, PvMSP-1 and PvAMA-1, and the cross-reactivity between these antigens using plasma from acute malaria infected patients living in the central region of China and in the western border of Thailand. P. vivax endemicity is found in central China whereas both P. vivax and P. falciparum are endemic in Thailand. There was an increased level of anti-PvMSP-1/anti-PvAMA-1 in both populations. An elevated level of antibodies to total P. vivax proteins and low level of antibodies to total P. falciparum proteins was found in acute P. vivax infected Chinese, suggesting antibody cross-reactivity between the two species. P. vivax infected Thai patients had both anti-P. vivax and anti-P. falciparum antibodies as expected since both species are present in Thailand. More information on humoral and cell mediated immunity during acute P. vivax-infection in the area where only single P. vivax species existed is of great interest in the relation of building up anti-disease severity caused by P. falciparum. This knowledge will support vaccine development in the future.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84938843132&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/35119
ISSN: 16112156
Appears in Collections:Scopus 2011-2015

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