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Title: HLA-DRB1 and HLA-DQB1 are associated with adult-onset immunodeficiency with acquired anti-interferon-gamma autoantibodies
Authors: Manop Pithukpakorn
Ekkapong Roothumnong
Nasikarn Angkasekwinai
Bhoom Suktitipat
Anunchai Assawamakin
Voravich Luangwedchakarn
Pinklow Umrod
Wanna Thongnoppakhun
Suporn Foongladda
Yupin Suputtamongkol
Faculty of Medicine, Siriraj Hospital, Mahidol University
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 26-May-2015
Citation: PLoS ONE. Vol.10, No.5 (2015)
Abstract: © 2015 Pithukpakorn et al. Recently a newly identified clinical syndrome of disseminated non-tuberculous mycobacterial diseases (with or without other opportunistic infections in adult patients who were previously healthy, has been recognized in association with an acquired autoantibody to interferon-gamma. This syndrome is emerging as an important cause of morbidity and mortality, especially among people of Asian descent. Trigger for the production of this autoantibody remains unknown, but genetic factors are strongly suspected to be involved. We compared HLA genotyping between 32 patients with this clinical syndrome, and 38 controls. We found that this clinical syndrome was associated with very limited allele polymorphism, with HLA-DRB1 and DQB1 alleles, especially HLA-DRB1∗15:01, DRB1∗16:02, DQB1∗05:01andDQB1∗05:02. Odds ratio of DRB1∗15:01, DRB1∗16:02, DQB1∗05:01 and DQB1∗05:02were7.03 (95% CI,2.18-22.69, P<0.0001, 9.06 (95% CI, 2.79-29.46, P<0.0001), 6.68 (95% CI, 2.29-19.52, P = 0.0004), and 6.64 (95% CI, 2.30-19.20, P = 0.0004), respectively. Further investigation is warranted to provide better understanding on pathogenesis of this association.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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