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dc.contributor.authorManop Pithukpakornen_US
dc.contributor.authorEkkapong Roothumnongen_US
dc.contributor.authorNasikarn Angkasekwinaien_US
dc.contributor.authorBhoom Suktitipaten_US
dc.contributor.authorAnunchai Assawamakinen_US
dc.contributor.authorVoravich Luangwedchakarnen_US
dc.contributor.authorPinklow Umroden_US
dc.contributor.authorWanna Thongnoppakhunen_US
dc.contributor.authorSuporn Foongladdaen_US
dc.contributor.authorYupin Suputtamongkolen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationPLoS ONE. Vol.10, No.5 (2015)en_US
dc.description.abstract© 2015 Pithukpakorn et al. Recently a newly identified clinical syndrome of disseminated non-tuberculous mycobacterial diseases (with or without other opportunistic infections in adult patients who were previously healthy, has been recognized in association with an acquired autoantibody to interferon-gamma. This syndrome is emerging as an important cause of morbidity and mortality, especially among people of Asian descent. Trigger for the production of this autoantibody remains unknown, but genetic factors are strongly suspected to be involved. We compared HLA genotyping between 32 patients with this clinical syndrome, and 38 controls. We found that this clinical syndrome was associated with very limited allele polymorphism, with HLA-DRB1 and DQB1 alleles, especially HLA-DRB1∗15:01, DRB1∗16:02, DQB1∗05:01andDQB1∗05:02. Odds ratio of DRB1∗15:01, DRB1∗16:02, DQB1∗05:01 and DQB1∗05:02were7.03 (95% CI,2.18-22.69, P<0.0001, 9.06 (95% CI, 2.79-29.46, P<0.0001), 6.68 (95% CI, 2.29-19.52, P = 0.0004), and 6.64 (95% CI, 2.30-19.20, P = 0.0004), respectively. Further investigation is warranted to provide better understanding on pathogenesis of this association.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleHLA-DRB1 and HLA-DQB1 are associated with adult-onset immunodeficiency with acquired anti-interferon-gamma autoantibodiesen_US
Appears in Collections:Scopus 2011-2015

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