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Title: Characterization of plasmodium vivax early transcribed membrane protein 11.2 and exported protein 1
Authors: Yang Cheng
Feng Lu
Seong Kyun Lee
Deok Hoon Kong
Kwon Soo Ha
Bo Wang
Jetsumon Sattabongkot
Takafumi Tsuboi
Eun Taek Han
Kangwon National University
National Institute of Allergy and Infectious Diseases
Jiangsu Institute of Parasitic Diseases
Anhui Medical University
Mahidol University
Ehime University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-May-2015
Citation: PLoS ONE. Vol.10, No.5 (2015)
Abstract: © 2015 Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In Plasmodium, the membrane of intracellular parasites is initially formed during invasion as an invagination of the red blood cell surface, which forms a barrier between the parasite and infected red blood cells in asexual blood stage parasites. The membrane proteins of intracellular parasites of Plasmodium species have been identified such as early-transcribed membrane proteins (ETRAMPs) and exported proteins (EXPs). However, there is little or no information regarding the intracellular parasite membrane in Plasmodium vivax. In the present study, recombinant PvETRAMP11.2 (PVX-003565) and PvEXP1 (PVX-091700) were expressed and evaluated antigenicity tests using sera from P. vivax-infected patients. A large proportion of infected individuals presented with IgG antibody responses against PvETRAMP11.2 (76.8%) and PvEXP1 (69.6%). Both of the recombinant proteins elicited high antibody titers capable of recognizing parasites of vivax malaria patients. PvETRAMP11.2 partially co-localized with PvEXP1 on the intracellular membranes of immature schizont. Moreover, they were also detected at the apical organelles of newly formed merozoites of mature schizont. We first proposed that these proteins might be synthesized in the preceding schizont stage, localized on the parasite membranes and apical organelles of infected erythrocytes, and induced high IgG antibody responses in patients.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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