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dc.contributor.authorTyler S. Brownen_US
dc.contributor.authorChristopher G. Jacoben_US
dc.contributor.authorJoana C. Silvaen_US
dc.contributor.authorShannon Takala-Harrisonen_US
dc.contributor.authorAbdoulaye Djimdéen_US
dc.contributor.authorArjen M. Dondorpen_US
dc.contributor.authorMark Fukudaen_US
dc.contributor.authorHarald Noedlen_US
dc.contributor.authorMyaing Myaing Nyunten_US
dc.contributor.authorMyat Phone Kyawen_US
dc.contributor.authorMayfong Mayxayen_US
dc.contributor.authorTran Tinh Hienen_US
dc.contributor.authorChristopher V. Ploween_US
dc.contributor.authorMichael P. Cummingsen_US
dc.contributor.otherUniversity of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatologyen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherUniversity of Maryland School of Medicineen_US
dc.contributor.otherMedizinische Universitat Wienen_US
dc.contributor.otherMahosot Hospitalen_US
dc.contributor.otherUniversity of Health Sciencesen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherUniversity of Marylanden_US
dc.contributor.otherDepartment of Medical Research (Lower Myanmar)en_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherThe Johns Hopkins School of Medicineen_US
dc.identifier.citationInfection, Genetics and Evolution. Vol.30, (2015), 318-322en_US
dc.description.abstract© 2015 Elsevier B.V. Multiple transcontinental waves of drug resistance in Plasmodium falciparum have originated in Southeast Asia before spreading westward, first into the rest of Asia and then to sub-Saharan Africa. In vitro studies have suggested that hypermutator P. falciparum parasites may exist in Southeast Asia and that an increased rate of acquisition of new mutations in these parasites may explain the repeated emergence of drug resistance in Southeast Asia. This study is the first to test the hypermutator hypothesis using field isolates. Using genome-wide SNP data from human P. falciparum infections in Southeast Asia and West Africa and a test for relative rate differences we found no evidence of increased relative substitution rates in P. falciparum isolates from Southeast Asia. Instead, we found significantly increased substitution rates in Mali and Bangladesh populations relative to those in populations from Southeast Asia. Additionally we found no association between increased relative substitution rates and parasite clearance following treatment with artemisinin derivatives.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titlePlasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotypeen_US
Appears in Collections:Scopus 2011-2015

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