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Title: Identification of immunodominant cd4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E
Authors: Silvia Ratto-Kim
Mark S. De Souza
Jeffrey R. Currier
Nicos Karasavvas
John Sidney
Morgane Rolland
Anais Valencia-Micolta
Sirinan Madnote
Alessandro Sette
Sorachai Nitayaphan
Punnee Pitisuttuthum
Jaranit Kaewkungwal
Supachai Rerks-Ngarm
Robert O'Connell
Nelson Michael
Merlin L. Robb
Mary Marovich
Jerome H. Kim
Walter Reed Army Institute of Research
Armed Forces Research Institute of Medical Sciences, Thailand
La Jolla Institute for Allergy and Immunology
Mahidol University
Thailand Ministry of Public Health
National Institutes of Health, Bethesda
National Institute of Infectious Diseases
Water Reed Army Institute of Research
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 10-Feb-2015
Citation: PLoS ONE. Vol.10, No.2 (2015)
Abstract: We performed fine epitope mapping of the CD4+ responses in the ALVAC-HIV-AIDSVAX B/E prime-boost regimen in the Thai Phase III trial (RV144). Non-transformed Env-specific T cell lines established from RV144 vaccinees were used to determine the fine epitope mapping of the V2 and C1 responses and the HLA class II restriction. Data showed that there are two CD4+ epitopes contained within the V2 loop: one encompassing the α4β7 integrin binding site (AA179-181) and the other nested between two previously described genetic sieve signatures (AA169, AA181). There was no correlation between the frequencies of CD4+ fine epitope responses and binding antibody.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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