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Title: Bioactivity-guided separation of the active compounds in acacia pennata responsible for the prevention of Alzheimer's disease
Authors: Pattamapan Lomarat
Sirirat Chancharunee
Natthinee Anantachoke
Worawan Kitphati
Kittisak Sripha
Nuntavan Bunyapraphatsara
Mahidol University
Chiang Mai University
Keywords: Agricultural and Biological Sciences;Medicine
Issue Date: 1-Jan-2015
Citation: Natural Product Communications. Vol.10, No.8 (2015), 1431-1434
Abstract: The objective of this study was to evaluate the health benefits of plants used in Thai food, specifically Acacia pennata Willd., in Alzheimer's prevention. A. pennata twigs strongly inhibited β-amyloid aggregation. Bioactivity-guided separation of the active fractions yielded six known compounds, tetracosane (1), 1-(heptyloxy)-octadecane (2), methyl tridecanoate (3), arborinone (4), confertamide A (5) and 4-hydroxy-1-methyl-pyrrolidin-2-carboxylic acid (6). The structures were determined by spectroscopic analysis. Biological testing revealed that tetracosane (1) was the most potent inhibitor of β-amyloid aggregation, followed by 1-(heptyloxy)-octadecane (2) with IC50values of 0.4 and 12.3 μM. Methyl tridecanoate (3), arborinone (4) and 4-hydroxy-1-methyl-pyrrolidin-2-carboxylic acid (6) moderately inhibited β-amyloid aggregation. In addition, tetracosane (1) and methyl tridecanoate (3) weakly inhibited acetylcholinesterase (AChE). These results suggested that the effect of A. pennata on Alzheimer's disease was likely due to the inhibition of β-amyloid aggregation. Thus A. pennata may be beneficial for Alzheimer's prevention.
ISSN: 15559475
Appears in Collections:Scopus 2011-2015

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