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Title: Diarylheptanoids of curcuma comosa with inhibitory effects on nitric oxide production in macrophage RAW 264.7 Cells
Authors: Nilubon Sornkaew
Yuan Lin
Fei Wang
Guolin Zhang
Ratchanaporn Chokchaisiri
Ailian Zhang
Kanjana Wongkrajang
Parichat Suebsakwong
Pawinee Piyachaturawat
Apichart Suksamrarn
Ramkhamhaeng University
Chengdu Institute of Biology Chinese Academy of Sciences
University of Phayao
Zhejiang Agriculture and Forestry University
Pibulsongkram Rajabhat University
Mahidol University
Keywords: Agricultural and Biological Sciences
Issue Date: 1-Jan-2015
Citation: Natural Product Communications. Vol.10, No.1 (2015), 89-93
Abstract: Eight new diarylheptanoids, a 1.2:1 mixture of (3S)-And (3R)-1-(4-hydroxyphenyl)-7-phenyl-(4E,6E)-4,6-heptadien-3-ol (1a and 1b), a racemic mixture of (3S)-And (3R)-1-(4-hydroxyphenyl)-3-methoxy-7-phenyl-(4E,6E)-4,6-heptadiene (2a and 2b), a ca. 1:1 mixture of (3S)-And (3R)-1-(4-hydroxy-3-methoxyphenyl)-3-methoxy-7-phenyl)-(4E,6E)-4,6-heptadiene (3a and 3b), 3-Acetoxy-1-(3,4-dihydroxyphenyl)-7-phenylheptan-5-ol (4), (3R)-1-(4,5-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3,2-epoxide (5), and thirteen known diarylheptanoids, 6-12, a 3:1 mixture of 13a and 13b, and 14-17, were isolated from the rhizomes of Curcuma comosa from Sakon Nakhon, northeastern part of Thailand. The isolated compounds were evaluated for their antiinflammatory activities on the inhibition of lipopolysaccharide-induced nitric oxide production in macrophage RAW 264.7 cells and the diarylheptanoids 1a and 1b mixture and 14 exhibited potent inhibitory activity.
ISSN: 15559475
Appears in Collections:Scopus 2011-2015

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