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|Title:||Diarylheptanoids of curcuma comosa with inhibitory effects on nitric oxide production in macrophage RAW 264.7 Cells|
Chengdu Institute of Biology Chinese Academy of Sciences
University of Phayao
Zhejiang Agriculture and Forestry University
Pibulsongkram Rajabhat University
|Keywords:||Agricultural and Biological Sciences|
|Citation:||Natural Product Communications. Vol.10, No.1 (2015), 89-93|
|Abstract:||Eight new diarylheptanoids, a 1.2:1 mixture of (3S)-And (3R)-1-(4-hydroxyphenyl)-7-phenyl-(4E,6E)-4,6-heptadien-3-ol (1a and 1b), a racemic mixture of (3S)-And (3R)-1-(4-hydroxyphenyl)-3-methoxy-7-phenyl-(4E,6E)-4,6-heptadiene (2a and 2b), a ca. 1:1 mixture of (3S)-And (3R)-1-(4-hydroxy-3-methoxyphenyl)-3-methoxy-7-phenyl)-(4E,6E)-4,6-heptadiene (3a and 3b), 3-Acetoxy-1-(3,4-dihydroxyphenyl)-7-phenylheptan-5-ol (4), (3R)-1-(4,5-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3,2-epoxide (5), and thirteen known diarylheptanoids, 6-12, a 3:1 mixture of 13a and 13b, and 14-17, were isolated from the rhizomes of Curcuma comosa from Sakon Nakhon, northeastern part of Thailand. The isolated compounds were evaluated for their antiinflammatory activities on the inhibition of lipopolysaccharide-induced nitric oxide production in macrophage RAW 264.7 cells and the diarylheptanoids 1a and 1b mixture and 14 exhibited potent inhibitory activity.|
|Appears in Collections:||Scopus 2011-2015|
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