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Title: Combining electrochemical sensors with miniaturized sample preparation for rapid detection in clinical samples
Authors: Natinan Bunyakul
Antje J. Baeumner
Mahidol University
Universitat Regensburg
Cornell University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Engineering
Issue Date: 30-Dec-2015
Citation: Sensors (Switzerland). Vol.15, No.1 (2015), 547-564
Abstract: © 2014 by the authors; licensee MDPI, Basel, Switzerland. Clinical analyses benefit world-wide from rapid and reliable diagnostics tests. New tests are sought with greatest demand not only for new analytes, but also to reduce costs, complexity and lengthy analysis times of current techniques. Among the myriad of possibilities available today to develop new test systems, amperometric biosensors are prominent players—best represented by the ubiquitous amperometric-based glucose sensors. Electrochemical approaches in general require little and often enough only simple hardware components, are rugged and yet provide low limits of detection. They thus offer many of the desirable attributes for point-of-care/point-of-need tests. This review focuses on investigating the important integration of sample preparation with (primarily electrochemical) biosensors. Sample clean up requirements, miniaturized sample preparation strategies, and their potential integration with sensors will be discussed, focusing on clinical sample analyses.
ISSN: 14248220
Appears in Collections:Scopus 2011-2015

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