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Title: Pinocembrin attenuates gentamicin-induced nephrotoxicity in rats
Authors: Sasivimon Promsan
Krit Jaikumkao
Anchalee Pongchaidecha
Nipon Chattipakorn
Varanuj Chatsudthipong
Phatchawan Arjinajarn
Wilart Pompimon
Anusorn Lungkaphin
University of Phayao
Chiang Mai University
Mahidol University
Rajabhat University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 16-Dec-2015
Citation: Canadian Journal of Physiology and Pharmacology. Vol.94, No.8 (2015), 808-818
Abstract: © 2015, Canadian Science Publishing. All rights reserved. Oxidative stress mediated apoptosis of renal tubular cells is a major pathology of gentamicin-induced nephrotoxicity, which is one of the prevailing causes of acute renal failure. Pinocembrin is a major flavonoid found in rhizomes of fingerroot (Boesenbergia pandurata). It has pharmacological and biological activities including antimicrobial, anti-inflammatory, and antioxidant effects. Preclinical studies have suggested that pinocembrin protects rat brain and heart against oxidation and apoptosis induced by ischemia–reperfusion. The aim of the current study was to investigate the mechanisms of renoprotection elicited by pinocembrin in gentamicin-induced nephrotoxicity. Nephrotoxicity was induced in rats by intraperitoneal injection (i.p.) of gentamicin, and pinocembrin was administered via i.p. 30 min before gentamicin treatment for 10 days. Gentamicin-induced nephrotoxicity was indicated by the reduced renal function and renal Oat3 function and expression. Gentamicin treatment also stimulated Nrf2, HO-1, and NQO1, as well as the pro-apoptotic proteins Bax and caspase-3, concomitant with the attenuation of Bcl-XL expression in the renal cortical tissues. Pinocembrin pretreatment improved renal function and renal Oat3 function and reduced oxidative stress and apoptotic conditions. These findings indicate that pinocembrin has a protective effect against gentamicin-induced nephrotoxicity, which may be due in part to its antioxidant and anti-apoptotic effects, subsequently leading to improved renal function.
ISSN: 12057541
Appears in Collections:Scopus 2011-2015

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