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Title: Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa
Authors: Brandyce St. Laurent
Becky Miller
Timothy A. Burton
Chanaki Amaratunga
Sary Men
Siv Sovannaroth
Michael P. Fay
Olivo Miotto
Robert W. Gwadz
Jennifer M. Anderson
Rick M. Fairhurst
National Institute of Allergy and Infectious Diseases
National Centre for Parasitology, Entomology and Malaria Control
Mahidol University
Wellcome Trust Sanger Institute
University of Oxford
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 20-Oct-2015
Citation: Nature Communications. Vol.6, (2015)
Abstract: © 2015 Macmillan Publishers Limited. Artemisinin-resistant Plasmodium falciparum parasites are rapidly spreading in Southeast Asia, yet nothing is known about their transmission. This knowledge gap and the possibility that these parasites will spread to Africa endanger global efforts to eliminate malaria. Here we produce gametocytes from parasite clinical isolates that displayed artemisinin resistance in patients and in vitro, and use them to infect native and non-native mosquito vectors. We show that contemporary artemisinin-resistant isolates from Cambodia develop and produce sporozoites in two Southeast Asian vectors, Anopheles dirus and Anopheles minimus, and the major African vector, Anopheles coluzzii (formerly Anopheles gambiae M). The ability of artemisinin-resistant parasites to infect such highly diverse Anopheles species, combined with their higher gametocyte prevalence in patients, may explain the rapid expansion of these parasites in Cambodia and neighbouring countries, and further compromise efforts to prevent their global spread.
ISSN: 20411723
Appears in Collections:Scopus 2011-2015

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