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Title: Janus kinase 2 negative polycythemia vera
Authors: Pravinwan Thungthong
Supat Chamnanchanunt
Tawatchai Suwanban
Chajchawan Nakhakes
Kunapa Iam-Arunthai
Rajavithi Hospital
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Oct-2015
Citation: Asian Biomedicine. Vol.9, No.5 (2015), 697-700
Abstract: Background: A Janus kinase 2 (JAK2) mutation polycythemia vera (PV) is a common manifestation of stem cell disorder. However, available data on the clinical and treatment response of JAK2-negative PV patients are limited. Objectives: We report the case and clinical course of a patient with PV and left hemiparesis who was JAK2V617- negative. Methods: We conducted a literature review and compared our patient with previously published reports of JAK2-negative patients with PV. Results: Our patient presented with hemiparesis without a previous history of hematological disease. He was diagnosed with PV based on the British Committee for Standards in Haematology guidelines 2007. He underwent only phlebotomy with subsequent improvement of his neurological condition. He was discharged with therapeutic phlebotomy for one and a half months. Conclusions: Although this rare condition required complex diagnostic criteria, the patient achieved good clinical outcome with therapeutic phlebotomy alone.
ISSN: 1875855X
Appears in Collections:Scopus 2011-2015

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