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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/35376
Title: HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
Authors: Holly Janes
Joshua T. Herbeck
Sodsai Tovanabutra
Rasmi Thomas
Nicole Frahm
Ann Duerr
John Hural
Lawrence Corey
Steve G. Self
Susan P. Buchbinder
M. Juliana McElrath
Robert J. O'Connell
Robert M. Paris
Supachai Rerks-Ngarm
Sorachai Nitayaphan
Punnee Pitisuttihum
Jaranit Kaewkungwal
Merlin L. Robb
Nelson L. Michael
James I. Mullins
Jerome H. Kim
Peter B. Gilbert
Morgane Rolland
Fred Hutchinson Cancer Research Center
University of Washington, Seattle
Walter Reed Army Institute of Research
HJF
Armed Forces Research Institute of Medical Sciences, Thailand
Thailand Ministry of Public Health
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Oct-2015
Citation: Nature Medicine. Vol.21, No.10 (2015), 1139-1141
Abstract: © 2015 Nature America, Inc. All rights reserved. Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found - in two different cohorts - that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84943663211&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/35376
ISSN: 1546170X
10788956
Appears in Collections:Scopus 2011-2015

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