Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Secretory autophagy
Authors: Marisa Ponpuak
Michael A. Mandell
Tomonori Kimura
Santosh Chauhan
Cédric Cleyrat
Vojo Deretic
Mahidol University
University of New Mexico Health Sciences Center
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Aug-2015
Citation: Current Opinion in Cell Biology. Vol.35, (2015), 106-116
Abstract: © 2015 Elsevier Ltd. Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less intuitive but biologically distinct non-degradative roles. One manifestation of these functions of the autophagic machinery is the process termed secretory autophagy. Secretory autophagy facilitates unconventional secretion of the cytosolic cargo such as leaderless cytosolic proteins, which unlike proteins endowed with the leader (N-terminal signal) peptides cannot enter the conventional secretory pathway normally operating via the endoplasmic reticulum and the Golgi apparatus. Secretory autophagy may also export more complex cytoplasmic cargo and help excrete particulate substrates. Autophagic machinery and autophagy as a process also affect conventional secretory pathways, including the constitutive and regulated secretion, as well as promote alternative routes for trafficking of integral membrane proteins to the plasma membrane. Thus, autophagy and autophagic factors are intimately intertwined at many levels with secretion and polarized sorting in eukaryotic cells.
ISSN: 18790410
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.