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Title: Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death
Authors: Kannan Badri Narayanan
Manaf Ali
Barry J. Barclay
Qiang Cheng
Leandro D'Abronzo
Rita Dornetshuber-Fleiss
Paramita M. Ghosh
Michael J. Gonzalez Guzman
Tae Jin Lee
Po Sing Leung
Lin Li
Suidjit Luanpitpong
Edward Ratovitski
Yon Rojanasakul
Maria Fiammetta Romano
Simona Romano
Ranjeet Kumar Sinha
Clement Yedjou
Fahd Al-Mulla
Rabeah Al-Temaimi
Amedeo Amedei
Dustin G. Brown
Elizabeth P. Ryan
Annamaria Colacci
Roslida A. Hamid
Chiara Mondello
Jayadev Raju
Hosni K. Salem
Jordan Woodrick
Ivana Scovassi
Neetu Singh
Monica Vaccari
Rabindra Roy
Stefano Forte
Lorenzo Memeo
Seo Yun Kim
William H. Bisson
Leroy Lowe
Hyun Ho Park
Yeungnam University
Universiti Sultan Zainal Abidin
Plant Biotechnologies Inc
Southern Illinois University
University of California, Davis
Universitat Wien
University of Puerto Rico
Chinese University of Hong Kong
Mahidol University
The Johns Hopkins School of Medicine
West Virginia University Robert C. Byrd Health Sciences Center
Universita degli Studi di Napoli Federico II
Scripps Research Institute
Jackson State University
University of Kuwait
Universita degli Studi di Firenze
Colorado State University
Environmental Protection and Health Prevention Agency
Universiti Putra Malaysia
Consiglio Nazionale delle Ricerche
Toxicology Research Division
Cairo University
Lombardi Comprehensive Cancer Center
Chhatrapati Shahuji Maharaj Medical University
Mediterranean Institute of Oncology
Korea Cancer Center Hospital
Oregon State University
Getting to Know Cancer
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jun-2015
Citation: Carcinogenesis. Vol.36, (2015), S89-S110
Abstract: © The Author 2015. Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of prosurvival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of proapoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.
ISSN: 14602180
Appears in Collections:Scopus 2011-2015

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