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dc.contributor.authorWilliam H. Goodsonen_US
dc.contributor.authorLeroy Loween_US
dc.contributor.authorDavid O. Carpenteren_US
dc.contributor.authorMichael Gilbertsonen_US
dc.contributor.authorAbdul Manaf Alien_US
dc.contributor.authorAdela Lopez de Cerain Salsamendien_US
dc.contributor.authorAhmed Lasfaren_US
dc.contributor.authorAmancio Carneroen_US
dc.contributor.authorAmaya Azquetaen_US
dc.contributor.authorAmedeo Amedeien_US
dc.contributor.authorAmelia K. Charlesen_US
dc.contributor.authorAndrew R. Collinsen_US
dc.contributor.authorAndrew Warden_US
dc.contributor.authorAnna C. Salzbergen_US
dc.contributor.authorAnnamaria Colaccien_US
dc.contributor.authorAnn Karin Olsenen_US
dc.contributor.authorArthur Bergen_US
dc.contributor.authorBarry J. Barclayen_US
dc.contributor.authorBinhua P. Zhouen_US
dc.contributor.authorCarmen Blanco-Aparicioen_US
dc.contributor.authorCarolyn J. Bagloleen_US
dc.contributor.authorChenfang Dongen_US
dc.contributor.authorChiara Mondelloen_US
dc.contributor.authorChia Wen Hsuen_US
dc.contributor.authorChristian C. Nausen_US
dc.contributor.authorClement Yedjouen_US
dc.contributor.authorColleen S. Curranen_US
dc.contributor.authorDale W. Lairden_US
dc.contributor.authorDaniel C. Kochen_US
dc.contributor.authorDanielle J. Carlinen_US
dc.contributor.authorDean W. Felsheren_US
dc.contributor.authorDebasish Royen_US
dc.contributor.authorDustin G. Brownen_US
dc.contributor.authorEdward Ratovitskien_US
dc.contributor.authorElizabeth P. Ryanen_US
dc.contributor.authorEmanuela Corsinien_US
dc.contributor.authorEmilio Rojasen_US
dc.contributor.authorEun Yi Moonen_US
dc.contributor.authorEzio Laconien_US
dc.contributor.authorFabio Marongiuen_US
dc.contributor.authorFahd Al-Mullaen_US
dc.contributor.authorFerdinando Chiaradonnaen_US
dc.contributor.authorFirouz Darroudien_US
dc.contributor.authorFrancis L. Martinen_US
dc.contributor.authorFrederik J. Van Schootenen_US
dc.contributor.authorGary S. Goldbergen_US
dc.contributor.authorGerard Wagemakeren_US
dc.contributor.authorGladys Nangamien_US
dc.contributor.authorGloria M. Calafen_US
dc.contributor.authorGraeme Williamsen_US
dc.contributor.authorGregory T. Wolfen_US
dc.contributor.authorGudrun Koppenen_US
dc.contributor.authorGunnar Brunborgen_US
dc.contributor.authorH. Kim Lyerlyen_US
dc.contributor.authorHarini Krishnanen_US
dc.contributor.authorHasiah Ab Hamiden_US
dc.contributor.authorHemad Yasaeien_US
dc.contributor.authorHideko Soneen_US
dc.contributor.authorHiroshi Kondohen_US
dc.contributor.authorHosni K. Salemen_US
dc.contributor.authorHsue Yin Hsuen_US
dc.contributor.authorHyun Ho Parken_US
dc.contributor.authorIgor Koturbashen_US
dc.contributor.authorIsabelle R. Miousseen_US
dc.contributor.authorA. Ivana Scovassien_US
dc.contributor.authorJames E. Klaunigen_US
dc.contributor.authorJan Vondráčeken_US
dc.contributor.authorJayadev Rajuen_US
dc.contributor.authorJesse Romanen_US
dc.contributor.authorJohn Pierce Wiseen_US
dc.contributor.authorJonathan R. Whitfielden_US
dc.contributor.authorJordan Woodricken_US
dc.contributor.authorJoseph A. Christopheren_US
dc.contributor.authorJosiah Ochiengen_US
dc.contributor.authorJuan Fernando Martinez-Lealen_US
dc.contributor.authorJudith Weiszen_US
dc.contributor.authorJulia Kravchenkoen_US
dc.contributor.authorJun Sunen_US
dc.contributor.authorKalan R. Prudhommeen_US
dc.contributor.authorKannan Badri Narayananen_US
dc.contributor.authorKarine A. Cohen-Solalen_US
dc.contributor.authorKim Moorwooden_US
dc.contributor.authorLaetitia Gonzalezen_US
dc.contributor.authorLaura Souceken_US
dc.contributor.authorLe Jianen_US
dc.contributor.authorLeandro S. D'Abronzoen_US
dc.contributor.authorLiang Tzung Linen_US
dc.contributor.authorLin Lien_US
dc.contributor.authorLinda Gulliveren_US
dc.contributor.authorLisa J. McCawleyen_US
dc.contributor.authorLorenzo Memeoen_US
dc.contributor.authorLouis Vermeulenen_US
dc.contributor.authorLuc Leynsen_US
dc.contributor.authorLuoping Zhangen_US
dc.contributor.otherGetting to Know Canceren_US
dc.contributor.otherLancaster Universityen_US
dc.contributor.otherUniversity at Albany State University of New Yorken_US
dc.contributor.otherGetting to Know Canceren_US
dc.contributor.otherUniversiti Sultan Zainal Abidinen_US
dc.contributor.otherUniversidad de Navarraen_US
dc.contributor.otherRutgers Biomedical and Health Sciencesen_US
dc.contributor.otherHospital Universitario Virgen del Rocioen_US
dc.contributor.otherUniversita degli Studi di Firenzeen_US
dc.contributor.otherUniversity of Readingen_US
dc.contributor.otherUniversitetet i Osloen_US
dc.contributor.otherUniversity of Bathen_US
dc.contributor.otherPenn State College of Medicineen_US
dc.contributor.otherEnvironmental Protection and Health Prevention Agencyen_US
dc.contributor.otherNorwegian Institute of Public Healthen_US
dc.contributor.otherNational Research Council Canadaen_US
dc.contributor.otherUniversity of Kentuckyen_US
dc.contributor.otherCentro Nacional de Investigaciones Oncologicasen_US
dc.contributor.otherMcGill Universityen_US
dc.contributor.otherConsiglio Nazionale delle Ricercheen_US
dc.contributor.otherNational Center for Advancing Translational Sciencesen_US
dc.contributor.otherThe University of British Columbiaen_US
dc.contributor.otherJackson State Universityen_US
dc.contributor.otherUniversity of Wisconsin Madisonen_US
dc.contributor.otherWestern Universityen_US
dc.contributor.otherStanford University School of Medicineen_US
dc.contributor.otherNational Institute of Environmental Health Sciencesen_US
dc.contributor.otherCity University of New Yorken_US
dc.contributor.otherColorado State Universityen_US
dc.contributor.otherThe Johns Hopkins School of Medicineen_US
dc.contributor.otherUniversita degli Studi di Milanoen_US
dc.contributor.otherUniversidad Nacional Autonoma de Mexicoen_US
dc.contributor.otherSejong Universityen_US
dc.contributor.otherUniversita degli Studi di Cagliarien_US
dc.contributor.otherUniversity of Kuwaiten_US
dc.contributor.otherUniversity of Milano - Bicoccaen_US
dc.contributor.otherCollege of North Atlanticen_US
dc.contributor.otherMaastricht Universityen_US
dc.contributor.otherRowan Universityen_US
dc.contributor.otherHacettepe Universitesien_US
dc.contributor.otherMeharry Medical Collegeen_US
dc.contributor.otherColumbia University Medical Centeren_US
dc.contributor.otherUniversidad de Tarapaca de Aricaen_US
dc.contributor.otherUniversity of Michigan Medical Schoolen_US
dc.contributor.otherFlemish Institute for Technological Researchen_US
dc.contributor.otherDuke University Medical Centeren_US
dc.contributor.otherUniversiti Putra Malaysiaen_US
dc.contributor.otherBrunel University Londonen_US
dc.contributor.otherNational Institute for Environmental Studies of Japanen_US
dc.contributor.otherKyoto University Hospitalen_US
dc.contributor.otherCairo Universityen_US
dc.contributor.otherTzu Chi Universityen_US
dc.contributor.otherYeungnam Universityen_US
dc.contributor.otherUniversity of Arkansas for Medical Sciencesen_US
dc.contributor.otherIndiana Universityen_US
dc.contributor.otherAcademy of Sciences of the Czech Republicen_US
dc.contributor.otherToxicology Research Divisionen_US
dc.contributor.otherUniversity of Louisvilleen_US
dc.contributor.otherLouisville Veterans Administration Medical Centeren_US
dc.contributor.otherUniversity of Southern Maineen_US
dc.contributor.otherVall d`Hebron Institut de Oncologiaen_US
dc.contributor.otherLombardi Comprehensive Cancer Centeren_US
dc.contributor.otherUniversity of Cambridgeen_US
dc.contributor.otherDepartment of Cell Biologyen_US
dc.contributor.otherRush Universityen_US
dc.contributor.otherOregon State Universityen_US
dc.contributor.otherThe Cancer Institute of New Jerseyen_US
dc.contributor.otherVrije Universiteit Brusselen_US
dc.contributor.otherInstitucio Catalana de Recerca I Estudis Avancatsen_US
dc.contributor.otherCurtin Universityen_US
dc.contributor.otherDepartment of Health Western Australiaen_US
dc.contributor.otherUniversity of California, Davisen_US
dc.contributor.otherTaipei Medical Universityen_US
dc.contributor.otherChinese University of Hong Kongen_US
dc.contributor.otherUniversity of Otagoen_US
dc.contributor.otherVanderbilt Universityen_US
dc.contributor.otherMediterranean Institute of Oncologyen_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.contributor.otherUniversity of California, Berkeleyen_US
dc.contributor.otherNational Cancer Instituteen_US
dc.contributor.otherUniversita degli Studi di Napoli Federico IIen_US
dc.contributor.otherCentre de recherche en cancérologie de Lyonen_US
dc.contributor.otherUnited States Armyen_US
dc.contributor.otherIstituto Italiano di Tecnologiaen_US
dc.contributor.otherCalifornia Pacific Medical Centeren_US
dc.date.accessioned2018-11-23T09:42:32Z-
dc.date.available2018-11-23T09:42:32Z-
dc.date.issued2015-06-01en_US
dc.identifier.citationCarcinogenesis. Vol.36, (2015), S254-S296en_US
dc.identifier.issn14602180en_US
dc.identifier.issn01433334en_US
dc.identifier.other2-s2.0-84937708474en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937708474&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/35451-
dc.description.abstract© The Author 2015. Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/ mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937708474&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAssessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge aheaden_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1093/carcin/bgv039en_US
Appears in Collections:Scopus 2011-2015

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