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Title: Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter-and intracontinental transmission events
Authors: Vanessa K. Wong
Stephen Baker
Derek J. Pickard
Julian Parkhill
Andrew J. Page
Nicholas A. Feasey
Robert A. Kingsley
Nicholas R. Thomson
Jacqueline A. Keane
François Xavier Weill
David J. Edwards
Jane Hawkey
Simon R. Harris
Alison E. Mather
Amy K. Cain
James Hadfield
Peter J. Hart
Nga Tran Vu Thieu
Elizabeth J. Klemm
Dafni A. Glinos
Robert F. Breiman
Conall H. Watson
Samuel Kariuki
Melita A. Gordon
Robert S. Heyderman
Chinyere Okoro
Jan Jacobs
Octavie Lunguya
W. John Edmunds
Chisomo Msefula
Jose A. Chabalgoity
Mike Kama
Kylie Jenkins
Shanta Dutta
Florian Marks
Josefina Campos
Corinne Thompson
Stephen Obaro
Calman A. Maclennan
Christiane Dolecek
Karen H. Keddy
Anthony M. Smith
Christopher M. Parry
Abhilasha Karkey
E. Kim Mulholland
James I. Campbell
Sabina Dongol
Buddha Basnyat
Muriel Dufour
Don Bandaranayake
Take Toleafoa Naseri
Shalini Pravin Singh
Mochammad Hatta
Paul Newton
Robert S. Onsare
Lupeoletalalei Isaia
David Dance
Viengmon Davong
Guy Thwaites
Lalith Wijedoru
John A. Crump
Elizabeth De Pinna
Satheesh Nair
Eric J. Nilles
Duy Pham Thanh
Paul Turner
Sona Soeng
Mary Valcanis
Joan Powling
Karolina Dimovski
Geoff Hogg
Jeremy Farrar
Kathryn E. Holt
Wellcome Trust Sanger Institute
Addenbrooke's Hospital
University of Oxford
Nuffield Department of Clinical Medicine
London School of Hygiene & Tropical Medicine
Liverpool School of Tropical Medicine
Quadram Institute Bioscience
Institut Pasteur, Paris
Bio21 Molecular Science and Biotechnology Institute
University of Melbourne
University of Birmingham
Kenya Medical Research Institute
Centers for Disease Control and Prevention
Emory Global Health Institute
University of Liverpool
University of Malawi College of Medicine
Prins Leopold Instituut voor Tropische Geneeskunde
KU Leuven
National Institute for Biomedical Research
University Hospital of Kinshasa
Universidad de la Republica Instituto de Higiene
Ministry of Health
Fiji Health Sector Support Program
National Institute of Cholera and Enteric Diseases India
International Vaccine Institute, Seoul
Administracion Nacional de Laboratorios E Institutos de Salud Dr. Carlos G. Malbran
University of Nebraska Medical Center
University of Abuja
Bingham University
Novartis Vaccines Institute for Global Health
University of Witwatersrand
Nagasaki University
Murdoch Children's Research Institute
ESR - Environmental Science and Research
Samoa Ministry of Health
Organisation Mondiale de la Sante
Hasanuddin University
Mahosot Hospital
Tupua Tamasese Meaole Hospital
Mahidol University
Chelsea and Westminster Hospital
University of Otago
Public Health England
Angkor Hospital for Children
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 27-May-2015
Citation: Nature Genetics. Vol.47, No.6 (2015), 632-639
Abstract: © 2015 Nature America, Inc. All rights reserved. The emergence of multidrug-resistant (MDR) typhoid is a major global health threat affecting many countries where the disease is endemic. Here whole-genome sequence analysis of 1,832 Salmonella enterica serovar Typhi (S. Typhi) identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years. Our analysis identifies numerous transmissions of H58, including multiple transfers from Asia to Africa and an ongoing, unrecognized MDR epidemic within Africa itself. Notably, our analysis indicates that H58 lineages are displacing antibiotic-sensitive isolates, transforming the global population structure of this pathogen. H58 isolates can harbor a complex MDR element residing either on transmissible IncHI1 plasmids or within multiple chromosomal integration sites. We also identify new mutations that define the H58 lineage. This phylogeographical analysis provides a framework to facilitate global management of MDR typhoid and is applicable to similar MDR lineages emerging in other bacterial species.
ISSN: 15461718
Appears in Collections:Scopus 2011-2015

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