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|Title:||Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138|
Prince of Songkla University
Thailand National Center for Genetic Engineering and Biotechnology
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine|
|Citation:||Journal of Natural Products. Vol.78, No.4 (2015), 615-622|
|Abstract:||© 2015 The American Chemical Society and American Society of Pharmacognosy. Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC<inf>50</inf> value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC<inf>50</inf> value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC<inf>50</inf> value of 3.45 μM, it showed much weaker cytotoxic activity.|
|Appears in Collections:||Scopus 2011-2015|
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