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Title: A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase
Authors: Friederike I. Nollmann
Antje K. Heinrich
Alexander O. Brachmann
Christophe Morisseau
Krishnendu Mukherjee
Ángel M. Casanova-Torres
Frederic Strobl
David Kleinhans
Sebastian Kinski
Katharina Schultz
Michael L. Beeton
Marcel Kaiser
Ya Yun Chu
Long Phan Ke
Aunchalee Thanwisai
Kenan A.J. Bozhüyük
Narisara Chantratita
Friedrich Götz
Nick R. Waterfield
Andreas Vilcinskas
Ernst H.K. Stelzer
Heidi Goodrich-Blair
Bruce D. Hammock
Helge B. Bode
Goethe-Universitat Frankfurt am Main
University of California, Davis
Fraunhofer Institute for Molecular Biology and Applied Ecology IME
University of Wisconsin Madison
Cardiff Metropolitan University
Universitat Basel
Universitat Tubingen
Vietnamese Academy of Science and Technology
Naresuan University
Mahidol University
Warwick Medical School
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 23-Mar-2015
Citation: ChemBioChem. Vol.16, No.5 (2015), 766-771
Abstract: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
ISSN: 14397633
Appears in Collections:Scopus 2011-2015

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