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Title: Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: An analysis based on the EGAT study
Authors: Jintana Sirivarasai
Sukhumpun Kaojarern
Suwannee Chanprasertyothin
Pachara Panpunuan
Krittaya Petchpoung
Aninthita Tatsaneeyapant
Krongtong Yoovathaworn
Thunyachai Sura
Sming Kaojarern
Piyamit Sritara
Mahidol University
Kasetsart University
Health Office
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 22-Feb-2015
Citation: BioMed Research International. Vol.2015, (2015)
Abstract: © 2015 Jintana Sirivarasai et al. Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 g/dL) compared to normotensive (4.41 g/dL) and prehypertensive (4.55 g/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 g/dL and 9.67 mol/L) than those with CC genotype (5.32 g/dL and 8.31 mol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.
ISSN: 23146141
Appears in Collections:Scopus 2011-2015

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